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Hemodynamic characterization in hypertrophic cardiomyopathy after septal myectomy +/- mitral valve repair: a 4D-flow MRI study

Although this procedure has been performed for more than 20 years and clinical results after myectomy combined with AMVLE are satisfactory, very little is known about the effect of surgical myectomy intervention on the blood flow through the aortic…

TORBO: Research in Twente on Recurrences after Pelvic Organ Prolapse Surgery

Objective: This protocol describes a framework that will be used to create different studies. The general primary and secondary objectives of this protocol are stated below:Primary objective: Investigate the effect of surgery on the position and…

OPtimal stEnt deployment stRategy oF Contemporary sTents

Primary objectiveThe primary objective is to evaluate whether a standard pre- and postdilatation of the modern DES results in a more optimal stent implantation compared to DS as evaluated by OCT in patients with stable coronary artery disease.…

Value of MRCP+ And Liver Multiscan in the management of Dominant strictures in primary sclerosing cholangitis

Primary Objective: Assess the ability of MRCP+ and LMS to detect change in total biliary volume and cT1 value, 8 weeks after endoscopic treatment of dominant strictures, by a clinical decision rule.Secondary Objective(s): Assess natural course of…

Early prediction of treatment response in children with Inflammatory Bowel Disease with Intestinal Ultrasound

To assess the early predictive value of IUS for therapy response in children with IBD (new onset or known IBD).

Intraoperative arthroscopic near-infrared fluorescence imaging of the vascular perfusion of the meniscus in patients treated with meniscal repair

To investigate the possibility of NIR fluorescence intra-operative angiography of the meniscus using ICG in patients undergoing arthroscopic meniscal repair.

Exploring Metabolic Maturation in the Extremely Preterm Brain at Term Equivalent Age: EMMA study.

We will combine four 7 Tesla MRI markers in extremely preterm infants (MRSI; SWI; PC-MRI; ihMT) to assess (1) if they can predict outcome until 2 years of age; (2) if they are of added value to 3 Tesla prematurity (Kidokoro et al., 2013) and (3) if…

Photoplethysmography to detect circulatory arrest: A study in patients with induced cardiac arrest

1) To study PPG signal characteristics in relation to circulatory arrest in patients with induced circulatory arrest. 2) To construct a PPG-based algorithm for detection of circulatory arrest based on induced circulatory arrest data in patients. 3)…

Prospective, single-centre, feasibility study to evaluate the use of 18F-PSMA PET/CT in patients with biochemically active medullary thyroid cancer.

Therefore, this feasibility study will evaluate whether the 18F-PSMA PET/CT is capable of MTC lesion detection. Moreover, we will compare its ability to detect MTC lesions with a routinely used PET scan, the 18F-FDG PET. By exploring new tracers in…

Speech flexibility following oral cancer treatment: acoustic and kinematic explorations

The objective of this study is to investigate the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or…

Non-invasive electrophysiological monitoring on the obstetric high

To investigate the effect of implementing continuous antepartum eCTG monitoring at the OHC, on perinatal and maternal outcomes and obstetric care

Clinical outcomes and cost-effectiveness of a diagnostic and treatment strategy of upfront CTCA plus selective non-invasive functional imaging compared with standard care in patients with chest pain and suspected coronary artery disease

This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.

Performance and patient acceptance of a commercially available beverage as compared to an oral glucose solution for oral glucose tolerance tests in cystic fibrosis (CF) patients who are screened for CF-related diabetes.

Primary Objective: To compare the performance of a glucose tolerance test (*AATT*) with a commercially available beverage to the results of the conventional OGTT with respect to diagnosing IGT and CFRD in patients with CF. Secondary Objective(s): To…