23 results
The study purpose is to evaluate the acute and long term clinical performance and safety of the Evolut* PRO System used in routine hospital setting for the treatment of symptomatic native aortic valve stenosis or a stenosed, insufficient, or…
To compare MIDP with ODP regarding radical resection rate) for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic body or tail.
Main objective: To map the natural course of the visual and hearing deterioration in Usher Syndrome type 2 for upcoming genetic therapy studies.Secondary Objective 1): To determine a. the necessary type of (combined) examinations, b. the sample size…
The objective of this study is to assess long-term safety and efficacy durability of levoketoconazole as chronic treatment for endogenous Cushing*s Syndrome (CS).
Our primary objective is to assess the postprandial anabolic response to mixed meal testing in both young and elderly, healthy volunteers. Our secondary objectives are to assess the effect of MMT on glucoregulatory and gut hormones, lipid profiles,…
To analyze the protective effect of azelastine/fluticasone propionate against exercise-induced airway narrowing by measuring inspiratory and expiratory airflow limitation and airway resistance and reactance in asthmatic children.
The objective is to gain more insight in:1. Possible causative agents of Kawasaki disease. At the moment no single causative agent has been identified despite the strong suspicion of an infectious etiology of the disease.2. Genetic factors related…
The standard first-line therapy for mUC patients is platinum-based chemotherapy, most commonly cisplatin. For patients that progress during or after platinum-based chemotherapy, anti-PD(L)1 therapy can be used, showing durable responses in a subset…
The primary study objective is to assess protein intake at the end of the first treatment cycle in patients with CRC or NSCLC undergoing first line treatment with chemo-, concurrent chemoradio- or immunotherapy who are receiving…
The primary objective is to assess diagnostic accuracy of MRDTI/BTI for first and recurrent CVT in patients referred for MRI/MRV in the setting of routine clinical setting. The secondary objectives are to optimize MRDTI/BTI sequences for imaging…
We aim to identify immunological parameters during (immune)therapy. We will study the effect of (immune)therapy on generic immune mediators and more specifically for NK cell, T effector and Treg cell functionality. Furthermore, we will explore DNX…
To compare the clinical and angiographic outcomes of a strategy of native vessel PCI with SVG PCI in patients with prior CABG presenting with SVG failure and a clinical indication for repeat revascularization, as determined by the local Heart Team.
The academic network of GPs *PrimEUR* in Rotterdam and the South-West of the Netherlands consists of 12 GP health centers. In addition another 14 GP practices will be recruited. All eligible children aged 6 to 12 years old in the participating GP…
To develop a prediction model for women with one previous caesarean section by combining assessment of the lower uterine segment with an extensive antepartum history taking and postpartum follow up.
Given the above mentioned gaps in knowledge, the aim of this project is to1) Describe the midterm and long-term outcomes of (primary and revision) total hip, total knee and shoulder replacement surgery in terms of health status as a whole,…
Main objective: To assess the effectiveness of MYSelf in comparison to care as usual in improving quality of life and symptom severity. Secondary objectives: 1) To investigate which characteristics of primary care professionals (General…
To assess the pharmacokinetics of various cytotoxic agents (carboplatin, cisplatin, cytarabine, dactinomycin, daunorubicin, dinutuximab bèta, doxorubicin, etoposide, methotrexate, vincristine or thiotepa) and kinase inhibitors (ALK, RAS pathway,…
1) determine the percentage of children with probable significant fibrosis (F>=2) using FibroScan®, when screening children based on the NASPGHAN 2017 guideline.2) determine the cost-effectiveness of screening for NAFLD when following the…
The objective of the study is to establish a data infrastructure to investigate the degree in which current and previous generations of young-old are characterised by healthy and successful ageing.
• To assess the relation between 18F-PD-L1 PET/CT outcome measures and progression-free survival of >=9 months according to RECIST 1.1.• To assess the relation between 18F-PD-L1 PET/CT outcome measures and patient outcome in terms of PFS and…