147 results
The study purpose is to evaluate the acute and long term clinical performance and safety of the Evolut* PRO System used in routine hospital setting for the treatment of symptomatic native aortic valve stenosis or a stenosed, insufficient, or…
To compare MIDP with ODP regarding radical resection rate) for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic body or tail.
Main objective: To map the natural course of the visual and hearing deterioration in Usher Syndrome type 2 for upcoming genetic therapy studies.Secondary Objective 1): To determine a. the necessary type of (combined) examinations, b. the sample size…
The objective of this study is to assess long-term safety and efficacy durability of levoketoconazole as chronic treatment for endogenous Cushing*s Syndrome (CS).
Our primary objective is to assess the postprandial anabolic response to mixed meal testing in both young and elderly, healthy volunteers. Our secondary objectives are to assess the effect of MMT on glucoregulatory and gut hormones, lipid profiles,…
To analyze the protective effect of azelastine/fluticasone propionate against exercise-induced airway narrowing by measuring inspiratory and expiratory airflow limitation and airway resistance and reactance in asthmatic children.
To identify molecular biomarker profiles that are associated with cervical tumorigenesis, and that can be used for development of an algorithm for detection of low grade CIN1, CIN2, CIN3 and cervical cancer. The algorithm should provide advice for…
Primary objectives: To evaluate the efficacy of long-term prophylactic treatment with deucrictibant (PHA-022121) in preventing breakthrough angioedema attacks in patients with AAE-C1-INH. Secondary objectives: To evaluate the safety of long-term…
This study aims to determine the effect of nocturnal versus daytime cyclic infusion of parenteral nutrition in adult chronic intestinal failure patients on bone turnover, glucose metabolism, nitrogen balance, sleep and wake rhythm and clock genes…
The primary objective of this study is to determine the nutritional intake, nutritional status, and physical activity level at various moments post-lower limb amputation (i.e., during hospital admission for amputation, at 5 weeks post-amputation, at…
To study the human adult cochlea, in specific it's RNA and protein expression patterns and morphology.
Primary Objective: To prospectively identify, in routine daily practice, the impact of radiotherapy to extremities, with regard to the incidence of (severe) ALT or AST elevations in STS patients (all grades, no systemic therapy). Secondary Objective…
The objective of this study is to investigate the feasibility of using MT and CEST MRI for in vivo monitoring of gastric protein digestion (coagulation and breakdown). This will be done by studying the effect of heating on gastric protein…
The standard first-line therapy for mUC patients is platinum-based chemotherapy, most commonly cisplatin. For patients that progress during or after platinum-based chemotherapy, anti-PD(L)1 therapy can be used, showing durable responses in a subset…
In the present study we aim to investigate the effectiveness of short-term schema group therapy (protocol of de Jager and Burger) on (1) persistent anxiety and depressive symptoms, and (2) dysfunctional schemas, experiential avoidance and the mode…
This study evaluates the efficacy and applicability of schema therapy for anorexia nervosa.
The primary study objective is to assess protein intake at the end of the first treatment cycle in patients with CRC or NSCLC undergoing first line treatment with chemo-, concurrent chemoradio- or immunotherapy who are receiving…
This study aims to demonstrate superiority of the research intervention (over standard of care) in [1] surgical success and [2] cost-effectiveness and non-inferiority in morbidity
The primary objective is to assess diagnostic accuracy of MRDTI/BTI for first and recurrent CVT in patients referred for MRI/MRV in the setting of routine clinical setting. The secondary objectives are to optimize MRDTI/BTI sequences for imaging…