167 results
To evaluate the potential attenuating effects of an eight-week supplementation with 200 mg OPCs per day on macro- and microvascular function as well as on systemic biomarkers of inflammation and oxidative stress in healthy smoking subjects.
This study will evaluate the effect of approximately 10 years of pravastatin treatment on IMT in young adults with FH. Furthermore, safety parameters and psychological aspects with respect to early treatment initiation will be investigated.
In this trial, current usual care concerning cardiovascular education is described. Second aim is to study what is understood of this education by the patient. Last aim is to study what effect training of GP's on this subject will have on the…
The main objective of the study is to evaluate the effectiveness of an individually- based lifestyle intervention for male workers with an elevated CVD risk in the construction industry in The Netherlands.
To assess the effect of increased intake of cis9,trans11-CLA on development of atherosclerosis, as assessed with aortic pulse wave velocity and on alternative biomarkers.
The objective of this study is to demonstrate (1) the superior efficacy of VTE prophylaxis with oral rivaroxaban 10 mg once daily administered for 35 ± 4 days to SC enoxaparin 40 mg once daily (OD) administered for 10 ± 4 days in men and women aged…
For the Einstein-DVT evaluation. The primary efficacy objective is to evaluate whether rivaroxaban is at least as effective as enoxaparin/VKA in the treatment of patients with acute symptomatic deep-vein thrombosis (DVT) without symptomatic…
The primary objective of the study is to determine the effect of atazanavir-induced hyperbilirubinemia on systemic activation of the innate immune response induced by human endotoxemia.Secondary objectives are:- To determine if the vascular…
Primary1. To determine whether treatment with an aliskiren-based regimen (in part combined with amlodipine or hydrochlorothiazide) compared to a non-aliskiren based regimen, both on top of non-study BP lowering agents where applicable, reduces the…
The primary aim of this study is to investigate if a tight multiple cardiovascular risk reduction program is effective in reducing progression of Intima media thickness progression (subclinical atherosclerosis) in patients with RA compared to usual…
To determine whether a dosing algorithm containing genetic information increases the time within therapeutic INR range during anticoagulation therapy with phenprocoumon compared to a dosing regimen that does not contain this genetic information.…
This prospective randomised study has the primary objective to prove a reduction of postoperative wound infections after direct preoperative use of a microbial sealant in the form of Integuseal for vascular procedures on lower extremities. We aim at…
The overall aim of the study is to evaluate the effect of CVPE in Afro-Surinamese and Ghanaian who are treated for HTN in general practice and who have an uncontrolled blood pressure. (systolic BP > 140 mmHG and/or diastolic BP > 90…
The objective of this trial is to investigate whether remote ischemic preconditioning or remote ischemic postconditioning improves clinical outcome after coronary artery bypass grafting surgery, as measured by the incidence of postoperative atrial…
The results of this study will give better insights in the role of ADMA in the development of systemicendothelial dysfunction and the relation with mild renal insufficiency.
The objective of this study is to investigate what the value is of SET after a radiological or surgical intervention for peripheral arterial disease in the aorto-iliacal, femoro-popliteal and crural segments in comparison with a control group.
To develop an effective lifestyle intervention for cardiac patients based on self-regulation theory aimed at health behavior change and maintenance.
The objective is to study whether saturated fatty acids induce a different postprandial change in inflammatory markers than cis-polyunsaturated fatty acids.
To establish superiority of the biolimus-eluting (BiomatrixTM) stent compared with an otherwise identical bare-metal stent (GazelleTM) in acute ST-segment elevation myocardial infarction (STEMI) in terms of the composite endpoint of cardiac death,…
To determine whether a dosing algorithm containing genetic information increases the time within therapeutic INR range during anticoagulation therapy with acenocoumarol compared to a dosing regimen that does not contain this genetic information.…