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ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial.

Primary Objective: To establish that ACT guided heparinization results in safe and optimal anticoagulation during open AAA repair. We hypothesize that ACT guided heparinization will result in a decrease of thrombo-embolic complications, without a…

Highlow study: Low-molecular-weight heparin to prevent recurrent VTE in pregnancy: a randomized controlled trial of two doses

To evaluate the efficacy and safety of intermediate dose LMWH versus fixed low dose LMWH in pregnant women with a history of previous VTE.

DOAC Levels prior to Incision study: DALI study

To measure DOAC levels just before surgery of all DOAC patients in the LUMC with elective surgery for which ceasing of DOAC treatment is required.

Optimizing anti coagulant therapy in neurosurgical interventions in patients with an increased risk for thrombo-embolic complications.

There is a high degree of diversity in attributed risk on thrombosis in the neurosurgical patient cohort. Due to this diversity, insufficient power of performed studies and lack of careful phenotyping and description of risk factors in previous…

Anesthesia Geriatric Evaluation on predicting health related quality of life after peripheral vascular surgery in elderly patients.

1. To determine the influence of frailty on predicting an increase in HRQL in elderly peripheral vascular surgery patients. 2. To develop an 'AGE-VASC score' for predicting an increase in HRQL after cardiac surgery based on surgical risk…

AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

The purpose of the pivotal study is to determine the safety and efficacy of IMPEDE-FX RapidFill for increasing the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label EVAR stent graft…

Leiden Thrombosis Recurrence Risk Prevention: Tailored treatment after a first venous thromboembolism: (L-TRRiP study)

To determine which patients, individually classified for VTE ánd bleeding risk, will benefit from prolonged anticoagulant treatment without being unnecessarily exposed to its risks.

Nutritional intake, nutritional status and physical activity level in people who have undergone a major dysvascular lower limb amputation

The primary objective of this study is to determine the nutritional intake, nutritional status, and physical activity level at various moments post-lower limb amputation (i.e., during hospital admission for amputation, at 5 weeks post-amputation, at…

Prospective randomized multi-center controlled clinical investigation comparing PFO outcomes of the Occlutech Flex II PFO Occluder to standard of care PFO occlusion.

The purpose of this clinical study is the assessment of the safety and effectiveness of the Flex II PFO Occluder in the treatment of subjects 18 years of age or older who have had a cryptogenic stroke due to a presumed paradoxical embolism as…

Assessment of the pathophysioLogical bAsis of local tissue compliaNce using augmenteD iMAging techniques to identify Regional flow dynamiCs (LANDMARC): a study with focus on aorta ascendens

The LANDMARC study aims to reveal the undiscovered relationship between the WSS values and aortic strain. By doing this, it strives to achieve a better understanding of the origin, pathogenesis, and clinical presentation of cardiovascular disease (…

Personalized hemodynamically guided antihypertensive treatment in pregnant women with mild to moderate hypertension: a randomized controlled trial

To evaluate whether personalized antihypertensive treatment of mild to moderate gestational hypertension based on maternal hemodynamic profile leads to effective treatment of hypertension with better maternal and neonatal outcome compared to no…

Discontinuing Statins in Multimorbid Older Adults without Cardiovascular Disease (STREAM) - a randomized non-inferiority clinical trial

The primary objective is to compare a composite endpoint of major CV events and all-cause death between control and intervention group.Secondary objectives are the comparison of patient-centered outcomes between the two groups.

Prevalence and impact of high on-treatment platelet reactivity in patients with peripheral arterial disease

Primary Objective: Investigate the difference in composite endpoint MACE, major amputation, or target vessel revascularization in PAD Fontaine II patients with and without antiplatelet resistance as measured by a. VerifyNow b. Genetic testing of…

Effect of a vegetarian diet on innate immunity in patients with myocardial infarction and in healthy volunteers (FRESH-MI study)

To determine the effect of a five-week vegetarian diet on innate immunity of patients with a recent myocardial infarction and healthy participants.

A placebo-controlled, double-blind randomized trial evaluating the effect of etidronate in young patients with pseudoxanthoma elasticum on ectopic mineralization.

This study has been transitioned to CTIS with ID 2024-512133-33-00 check the CTIS register for the current data. Primary Objective To determine if 24 months of treatment with etidronate halts the progression of arterial calcification in the legs and…

Arterial properties of ulcerative colitis patients and unaffected controls; a cross-sectional outpatient clinic study.

This study is aimed at understanding status and future cardiovascular disease (CVD) risk in UC outpatients in remission undergoing different anti-inflammatory therapeutic regimens (tofacitinib (a JAK1 - inhibitor), anti-TNF (infliximab or adalimumab…

A pilot study assessing the feasibility of a randomized controlled trial evaluating aspirin in postpartum women at risk of developing venous thromboembolism

The purpose of this pilot trial is to determine whether it is feasible to conduct a full multicentre randomized controlled trial (RCT) to determine whether low-dose aspirin (ASA) is efficacious and safe at preventing postpartum venous…

Plaque reversal with Early, Aggressive Lipid Lowering

To determine whether plaques in young patients with familial hypercholesterolemia (aged below 50 years) are susceptible to significant plaque regression with early, aggressive lipid lowering therapy (statins, ezetimibe and/or PCSK9) according to…

Carotid Artery ImPlant for Trapping UpstReam Emboli
(CAPTURE) for Preventing Stroke in Atrial Fibrillation
Patients

To assess the safety, feasibility, and tolerability of the Vine* Embolic Protection System and implantation procedure in atrial fibrillation (AF) patients at high stroke risk who are unsuitable for oral anti-coagulants (OAC).

Apixaban versus antiplatelet drugs or no antithrombotic drugs after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation. A randomised phase II clinical trial.

Primary Objective: to obtain reliable estimates of the rates of vascular death and non-fatal stroke in patients with atrial fibrillation and a recent anticoagulation-associated ICH who are treated with apixaban versus those who are treated with APDs…