167 results
The primary objective of this study is to establish the safety and effectiveness of the WATCHMAN TM Left Atrial Appendage Closure (LAAC) Device including the post-implant medication regimen for subjects with non-valvular atrial fibrillation who are…
The current study aims to establish age-dependent and sex-specific normal values for novel imaging biomarkers using 4D flow MRI and CFD.
Our main goal is to establish whether there is difference in the effect between the use of aspirin, dualtherapy aspirin/clopidogrel, or ticagrelor on the occurrence of atherothrombotic events in patients following lower extremity peripheral…
The overall safety objective of this study is to assess the safety and tolerability of long-term therapy with ticagrelor compared to placebo in patients with T2DM at high risk of CV events, with or without background low-dose ASA therapy. Bleeding…
Primary Objective: Measure QoL (VEINES QoL/Sym) change in patients with DVO at one year after PTA and stenting compared to conventional therapy (short class II elastic compressions stockings, exercise, lymph drainage therapy and the use of (pain)…
To determine whether measuring drug levels combined with personalized feedback improves adherence and leads to a decrease in resistant hypertension after 12 months of follow-up.
The aim of the current study is to determine whether a *liberal* strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a *restrictive* approach to red-cell transfusion to avoid…
The objective of the study is to evaluate in a prospective setting the effect of body weight on anti-Xa levels in the blood after administration of prophylactic nadroparin 2850 IE to patients admitted to the hospital. Second, we want to see what the…
Information on the dynamics and shape of the stent graft and stented target vessels and how these change over time will improve our understanding about the fixation and/or sealing of the device, which may help in stent graft selection and in…
1. To investigate the efficacy of dual therapy (omitting acetylsalicylic acid) compared to triple therapy in patients with atrial fibrillation and acute coronary syndrome.2. To investigate the safety of dual therapy (omitting acetylsalicylic acid)…
To explore the impact of different types (high-intensity vs moderate-intensity cycling), modes (whole bodycycling vs local handgrip) and stimuli (exercise vs ischaemic) of preconditioning on the ability to protect endothelial damage in response to…
Rationale:A study reporting the frailty trajectories after vascular surgery is currently lacking. The aim of this study is to evaluate the influence of the surgical intervention on the different domains of frailty, by measuring the characteristics…
To establish the relationship between the presence of CYP2C19 loss-of-function alleles in patients receiving clopidogrel after EVAR and the incidence of atherothrombotic events.
To investigate the effect of a daily sachet of probiotics for 12 weeks vs placebo on vitamin K status in renal transplant recipients.
The primary objective is to greatly reduce incidence of ischaemic spinal cord injury (SCI, potentially resulting in permanent paraplegia) and mortality - the most devastating complications resulting from open surgical and thoracoabdominal…
To explore whether vigorous endurance exercise (i.e., running a marathon) alters the magnitude of cardiac damage following myocardial ischemia-reperfusion injury in amateur athletes through using an ex vivo rat heart model of myocardial infarction.
The objective of this study is to assess if 1) by using the Arctic Sun® 5000 Temperature Management System occurrence of fever can be prevented and 2) patients treated with the Arctic Sun® 5000 Temperature Management System have a better recovery…
The principal and primary research questions are:Primary objective: 1) What are the differences in clinical myocardial infarction (heart attack) rates and in stroke and death within 30 days of carotid stenting compared with carotid endarterectomy?…
Primary ObjectiveThe primary objective is to evaluate the effectiveness of adding Epanova to statin therapy (with or without ezetimibe) for lowering MACE (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, emergent/elective…
Primary: Time to first occurrence of MACE (cardiovascular death, myocardial infarction, or stroke) [Non-inferiority].Secondary: Time to first occurrence of MACE [Superiority], MACE or urgent revascularization for unstable angina, individual…