31 results
The principal goal of this study is to identify whether and how innate immune host factors predispose to the development of chronic Q-fever.
The main goal of this pilot study is to analyze if using the 7.0 Tesla MRI scanner potential markers predicting aneurysmal rupture (i.e thickness and enhancement of the aneurysmal wall) can be studied in IA patients.
1. The application of 4D flow MR imaging to analyse blood flow patterns (flow angle, flow asymmetry), regional vessel wall parameters (regional wall shear stress, vessel wall thickness) and pulsed-wave velocity in neoaortic root, carotid artery and…
To identify an AAA associated genes by a functional candidate gene approach.The identification of an AAA associated gene will have several impacts on this high prevalent disease:1. It will improve our understanding of the molecular pathways involved…
In the presented study we would like to investigate the genetic background of the AAA with a twofould objective, namely the possibility of presymptomatic diagnosis of the AAA and the definition of molecular mechanism as possible therapeutic targets.
Primary Objective: To determine the differences in function and morphology of the distinct abdominal adipose tissue depots (e.g. SAT, PVAT, OAT and MAT; see figure 1) in patients undergoing elective open abdominal aortic surgery.Secondary…
The main goal of the current study is to gain insight in the development and rupture rate of aneurysms and to detect potential markers that predict the risk of aneurysm rupture.
To gain a better insight into the genetic factors that play a role in the etiology of the thoracic aortic aneurysm with the following specific aims:1. Study of specific geneitc factos that play a role in the pathogenesis of both syndromic and non-…
The primary objective of the present study is to characterize the glucose metabolism in patients with SAH in the acute- and, sub acute phase and during follow-up. The secondary objectives are to relate glucose metabolism to clinical condition on…
The objective of the current study is to determine whether the wait-and-see policy affects anxiety levels and quality of life in patients with aortic abdominal aneurysms between 3 and 5.5 cm in diameter. Furthermore, we aim to examine the influence…
1) To unravel the pathogenesis of DCI by studying the time course of cerebral perfusion and vasospasm in patients with aneurysmal SAH with CT, and 2) to obtain a diagnostic tool for the detection of DCI on the basis of CT-perfusion (CTP) parameters…
To establish an operational reference database on intracranial aneurysms encompassing clinical and genetic data on at least 800 patients, 400 controls and 400 relatives of patients where a familial trait is recognized, together with imaging data on…
Correlation of FDG uptake and in vitro aneurysm wall tensile strength. (primary objective). The effect of aneurysm sac depressurisation, after endovascular aneurysm repair, on aneurysm wall inflammation (secondary objective).
To visualize occult endoleaks in patients after endovascular abdominal aortic aneurysm repair.
The aim of the study described in this protocol is the identification of genes involved in aortic aneurysm development. This will be achieved by characterization of large AA families, including pedigree investigations, diagnostic measurements (…
The main objective of this study is to find biomarkers for the prognosis of the BAV patients by investigating ECFC and EPC functioning, and to gain knowledge on physiological and pathological processes in patients by investigating molecular…
The current project aims to implement male-female specific insights into aortic root and ascending aorta characteristics into clinical practice, allowing better identification of high risk Thoracic Aortic Aneurysm (TAA) patients and better timing of…
To identify which patient characteristics and biomarkers can contribute to a better prediction of complications in patients with thoracic aortic disease. This will result in better risk-prediction with reassurance of low-risk individuals and…
To compare the effects of a preoperative PA program in addition to usual care versus usual care only on the change in SB from baseline (T0) to the end of the preoperative (intervention) period (T1) in patients with TAD.
Primary Objectives: •To determine the correlation between AAA growth and the evolution of serum levels of proteases and cytokines.•To determine the correlation between AAA rupture and the evolution of serum levels of proteases and cytokines.•To…