563 results
Some studies have reported improved vascular function with the supplementation of L-arginine in participants with CVD. Several clinical studies have also begun the investigation of L-arginine supplementation in participants with PAD. This is…
To assess the safety and efficacy of the Orsiro Sirolimus Eluting Coronary Stent System in the treatment of subjects with up to three native de novo or restenotic (standard PTCA only) coronary artery lesions compared to the Xience coronary stent…
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
Primary ObjectivesTo evaluate the effect of MDCO-216 treatment on the change in PAV of a target coronary artery as measured by IVUS imaging following five weekly infusions of MDCO-216 (20 mg/kg) compared with placebo in subjects with a recent ACS.…
This research will have as aim to look at progression or decrease of vascular calcification in dialysis population with use of different phosphate binders. There is a possibility that differect phosphate binders bind vitamin K in a different way in…
Test the optimized MRI sequences/technology against CTA as gold standard, in terms ofimage quality, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), speed, and accuracy/reproducibility of extracted quantitative parameters.
To compare the safety and efficacy of the Tack Endovascular System* in subjects with peripheral artery disease (PAD) to a pre-defined performance goal (PG).
- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.
optimization of a new 3 Tesla Magnetic Resonance Imaging protocol for imaging of the aortic vessel wall in order to enhance the identification of individuals at highest risk of developing clinically manifest atherosclerosis
Primary objective: To investigate left ventricular diastolic function in AS-patients compared with osteoarthritis patients. Secondary objectives: To assess the prevalence of valvular heart diseases and conduction disturbances. To assess left…
The purpose of this trial is to evaluate the safety and effectiveness of the NovaCross* micro-catheter when used to facilitate crossing of Chronic Total Occlusion (CTO) lesions in coronary arteries. The procedure will be conducted on consenting…
Primary:2. To investigate the prevalence of vulnerable plaques, i.e. plaques with intraplaque hemorrhage on MRI, in individuals with type 2 diabetes, impaired and normal glucose tolerance and a minimal plaque thickness of 2mm on ultrasonography. To…
Primary Objectives:A. To assess the reproducibility and variability (interscan, intra- and interreader) of novel (DCE-)MRI techniques to measure vessel wall dimensions, wall shear stress and vessel wall permeability in healthy and cardiovascular…
To examine the hour-to-hour and day-to-day reproducibility of the CAV-test in young and older humans
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
With this study we will evaluate the following hypothesis: Does acute systemic inflammation induces plaque instability and could it be repsonsible for the elevated risk of cardiovascular events. Eventually this study can contribute to the knowledge…
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
To evaluate the safety and effectiveness of Orsiro for the treatment of subjects with up to 2 de novo atherosclerotic coronary artery lesions.
To answer the following research questions: 1. Do intimal arterial calcification and medial arterial calcification in the lower extremity arteries increase the occurrence of cardiovascular disease in people with a high risk of cardiovascular disease…