45 results
- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.
Primary Objective:- To assess lipid levels of STEMI patients over a long course. Secondary Objectives:- To assess the association between poorly controlled cholesterol and (apo) lipoprotein levels for the long term outcome in STEMI patients.- To…
The objective of the study can be defined into two goals1. Reduction of CIN using the Renalguard with furosemide forced diuresis in patients known with chronic kidney failure whom require an endovascular intervention of the lower limbs. 2. Early…
The primary aim of the proposed study is to assess whether stenting for symptomatic vertebral artery stenosis >= 50% is feasible and safe. A secondary aim is to assess the rate of new vascular events in the territory of the vertebrobasilar…
Objective: Our main objective is to evaluate the additional effect of omega-3 fatty acids on maximal walking distance in patients with IC receiving SET. Our secondary objective is to evaluate the effect of omega-3 fatty acids on hemorheological…
Is, when EE is kept constant, replacing sitting time by NEA more effective than exercise in improving glucose control in people with DM2?
Examine the impact of 7-day daily ischemic preconditioning on brachial artery endothelial function (measured as FMD%) in the dominant arm (i.e. local effect: primary objective) and contra-lateral arm (i.e. remote effect: secondary objective) in…
To examine the impact of age and physical fitness on the ability of ischaemic preconditioning to protect endothelial damage in response to ischaemia reperfusion injury in healthy humans. A secondary objective is to explore the role of Toll-like…
We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
The primary purpose of this study is to determine the relation between a physically active lifestyle and the primary and secondary prevention of diseases and death.Using an online questionnaire, we will approach all civilian participants of the…
The possibility to identify the risk of rupture of a carotid plaque will have tremendous impact in clinical decision making. Selection of candidates from surgery is based mainly on duplex ultrasonography, where now only the size of the stenosis is…
To study the protective effect of pre-treatment with metformin on flow mediated dilation after 20 minutes ischemia and 20 minutes reperfusion. If metformin treatment indeed limits endothelial IR-injury, a second study will be performed in the same…
Our objective is to assess whether patients with SM compared to controls have more advanced atherosclerosis assessed by carotid intima-media thickness (C-IMT) and carotid plaques and have a more adverse cardiovascular risk profile.
To examine the impact of walking training on the lifetime risk for cardiovascular disease in DMT2 and DMT1 patients and to assess whether these effects are preserved 3 months after the Nijmegen 4-Day marches. Results will be compared with a control…
Evaluation of the rise in serum creatinine and the incidence of CIN following angiography in patients treated with a short hydration regime during 1 hour with sodium bicarbonate compared to a hydration regime with saline during 6-24 hours.
Our main objective is to determine the effect of HO-1 induction by heme arginate infusion on insulin resistance and endothelial dysfunction related to MetS. Secondary objectives are to determine the effect on adipose tissue, adiponectin plasma level…
Primary Objective: comparing hemodynamic stability provided by titration of esmolol in addition to standard perioperative care including low-dose metoprolol to placebo and standard care.Secondary Objective(s): -comparing the incidence of…
This study will evaluate the effect of approximately 10 years of pravastatin treatment on IMT in young adults with FH. Furthermore, safety parameters and psychological aspects with respect to early treatment initiation will be investigated.
In this trial, current usual care concerning cardiovascular education is described. Second aim is to study what is understood of this education by the patient. Last aim is to study what effect training of GP's on this subject will have on the…
The primary aim of this study is to investigate if a tight multiple cardiovascular risk reduction program is effective in reducing progression of Intima media thickness progression (subclinical atherosclerosis) in patients with RA compared to usual…