340 results
Primary: To evaluate the safety of the study device in patients presenting with severe aortic stenosis (AS) considered to be high risk for surgery.Secondary: To evaluate adverse events and study device performance.
The primary objective of this study is to test the hypothesis that evacetrapib 130 mg daily, in comparison to placebo, reduces the incidence of the composite endpoint of cardiovascular (CV) death, myocardial infarction (MI), stroke, coronary…
To investigate the effect of anti-IL6 therapy with tocilizumab on subclinical arterial inflammation (endothelial dysfunction) and stiffness in patients with treatment resistant rheumatoid arthritis at baseline and after 6 months treatment
The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis
Some studies have reported improved vascular function with the supplementation of L-arginine in participants with CVD. Several clinical studies have also begun the investigation of L-arginine supplementation in participants with PAD. This is…
Primary ObjectivesTo evaluate the effect of MDCO-216 treatment on the change in PAV of a target coronary artery as measured by IVUS imaging following five weekly infusions of MDCO-216 (20 mg/kg) compared with placebo in subjects with a recent ACS.…
To compare the safety and efficacy of the Tack Endovascular System* in subjects with peripheral artery disease (PAD) to a pre-defined performance goal (PG).
This research will have as aim to look at progression or decrease of vascular calcification in dialysis population with use of different phosphate binders. There is a possibility that differect phosphate binders bind vitamin K in a different way in…
to identify novel molecular pathways resulting in premature atherosclerosis (PAS) in families where the traditional risk factors are not present / near absent.
PRIMARY OBJECTIVE The primary objective of this study is to evaluate the effect of ALN-PCSSC treatment on LDL-C levels at Day 180. SECONDARY OBJECTIVESThe secondary objectives of this study are to evaluate the effect of ALN-PCSSC on the following…
To determine the effect of IVT on walking distance after 6 and 12 weeks, 6 months and 1 year in patients with IC who are treated with a SET program. To determine the optimal timing for IVT within the SET program.
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
To assess the safety and efficacy of the Orsiro Sirolimus Eluting Coronary Stent System in the treatment of subjects with up to three native de novo or restenotic (standard PTCA only) coronary artery lesions compared to the Xience coronary stent…
The aim of the study is to compare the outcome of two DES with biodegradable polymer coatings separately (Orsiro and Synergy) versus an established third-generation durable polymer DES with proven efficacy and safety (Resolute Integrity) in an all…
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
With this study we will evaluate the following hypothesis: Does acute systemic inflammation induces plaque instability and could it be repsonsible for the elevated risk of cardiovascular events. Eventually this study can contribute to the knowledge…
In this study we would like to investigate whether repetitive allogeneic (lean donor) fecal transplantations can reduce liversteatosis and if so which (small) intestinal bacteria cause this inflammation in the liver resulting in subsequent chronic…
The primary objective will be the prevalence of medial arterial calcification, defined as an ABI * 1.3 and a TBI > 0.7, among hemophiliacs compared with non- hemophiliacs matched by sex and age.