330 results
The primary objective will be to assess whether cerebrovascular reactivity is impaired in patients with steno-occlusive disease of the vertebrobasilar artery .
PrimaryTo investigate sensitivity and specificity of 3.0 Tesla MRI and MRS for dimension and composition assessment of carotid artery plaques, in particularly those plaques with lipid rich necrotic cores (LRNC), with the aim to develop these…
The main objective of this pilot study is to evaluate the burden of an additional CTA and MRA procedure in patients, and to evaluate the quality of the CTA and MRA protocols.
To compare the confidence of the interventional radiologist in diagnosing and treating arterial stenoses and occlusions by digital subtraction angiography with contrast concentrations of 300, 240 and 140 mg iodine per ml. Also, we will compare the…
The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
Test the optimized MRI sequences/technology against CTA as gold standard, in terms ofimage quality, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), speed, and accuracy/reproducibility of extracted quantitative parameters.
* To determine the minimum effective dose of 5-aminolevulinic acid (Gliolan) for adequate MitoPO2 measurements during upper endoscopy.
to identify novel molecular pathways resulting in premature atherosclerosis (PAS) in families where the traditional risk factors are not present / near absent.
The main objective is to show whether imaging characteristics assessed at baseline can predict clinical events in patients with a 30-69 % symptomatic carotid stenosis.
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…
The main goal of this study is to assess the difference in local pulse wave velocity measured at three different points in the left and right carotid artery in healthy subjects and in patients with symptomatic and asymptomatic carotid plaques. As…
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
With this study we will evaluate the following hypothesis: Does acute systemic inflammation induces plaque instability and could it be repsonsible for the elevated risk of cardiovascular events. Eventually this study can contribute to the knowledge…
The main objective of this study is to assess the prevalence cardiovascular disease and the prevalence of risk factors for cardiovascular disease in patients with gout, and to quantify the risk for cardiovascular disease in patients with gout. The…
The primary objective will be the prevalence of medial arterial calcification, defined as an ABI * 1.3 and a TBI > 0.7, among hemophiliacs compared with non- hemophiliacs matched by sex and age.
To answer the following research questions: 1. Do intimal arterial calcification and medial arterial calcification in the lower extremity arteries increase the occurrence of cardiovascular disease in people with a high risk of cardiovascular disease…
The primary objective is to determine if MK-7 supplementation leads to stabilization or attenuation of ongoing calcium deposition, quantified by 18F- NaF PET/CT imaging in patients with type 2 diabetes.