174 results
In this investigation we want to regain more insight in the cardiovascular risk profile of RA patients. Also we want to find out which patients should have more attention concerning their cardiovascular risk profile and probably therapy for…
Primary: To investigate whether high-resolution MRI, 18F-FDG PET, and microemboli detection, or a combination of these techniques, enable to identify patients in the 30-69% stenosis group with an increased stroke risk. Secondary: To compare the…
1. To study the rate of change of diastolic and systolic LV function and LV structure, and the incidence of heart failure over a 7-year period in subjects with and without DM2 2. To study the potential determinants of accelerated deterioration of LV…
The primary objective of this study is to evaluate the diagnostic accuracy of coronary artery luminal stenosis and corresponding myocardium perfusion defects in patients with suspected coronary artery disease by use of volume computed tomography..…
To assess whether the non-invasive duplex method can reliably determine diameters and flow characteristics in the LIMA origin of LIMA-LAD versus Y-bypass grafts late after CABG in relation to-the number of distal anastomosis-the adaptation to…
The objective of this study is to to develop a selective and non-selective whole brain ASL perfusion stress test and at 3.0 Tesla based on ASL flow territory measurements.
To investigate the relation between premature cardiovascular disease and glycocalyx perturbation
Does flow-mediated dilatation of the brachial artery induce coagulation and inflammation? How long does this possible effect continue? Which parameters are influenced by FMD?
To study the effect of transient high blood glucose level on the brachial artery FMD response, and to determine the reproducibility of the measurements and observed effect.
Hypothesis: Changes in NIMA over 5 years, measured by repeated NIMA in both a low and a high-risk population, in relation to changes in traditional and new CV risk factors and incidence of CVD will reveal the main determinants of each of the NIMA.…
Correlate plaque characteristics, determined on high resolution 7 Tesla MRI, with cerebral damage ((clinically silent) cerebral (micro) infarcts or bleeds), also seen on 7 Tesla MRI. As gold standard histology of the plaques will be obtained
We hypothesize that intracranial vessel wall atheromas are an important underlying cause of middle cerebral artery obstruction. To test our hypothesis we will perform high resolution intracranial vessel wall imaging with a 7.0 Tesla MRI scanner in…
Calculating the incidence of atherosclerosis in patients undergoing a CT-scan of the abdomen for other reasons. Calculating incidence of untreated risk factors for CVD in patients with atherosclerosis on the CT-scan.
1. FDG PET scanning will permit evaluation of atherosclerotic disease in lower limbs (both density and activity of macrophages in local plaques) in patients with diabetes type 2 2. To obtain a more precise identification of ischemic borders…
To establish whether miRNA expression patterns in platelets, monocytes and plasma differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
The primary objective is identification of a set of genes as candidate monocyte markers for acute coronary complications and subsequent identification of a prognosis classifier to discriminate vulnerable, stable, and control subjects, based on the…
Main objective of this study is to develop an MRI protocol from which regional PWV can be assessed. An automated image analysis tool, indispensable for fast, reproducible and observer-independent data processing will be developed. The technique will…
Objectives of the study are to evaluate the clinical applicability of the PeriFlux System 5000 and to investigate the reproducability of its measurements on inter- (and intra-observer) variability.
To determine the inter- and intrarater reliability of 4 different methods to define stump volume in vivo, namely: water displacement method, Omega Tracer (Ohio Willow Wood), Design TT (Otto Bock) and circumference measurement (Sytzia-method).
To study the feasiblity of cardiac MRI at 3T and the potential benefits of the intravascular contrast agent gadofosveset for studying and quantifiaction of heart function and -perfusion.