157 results
To establish compare vessel wall dimensions and inflammation in AS with healthy matched control subjects with MRI and PET-FDG
The PRELHUDE study investigates the reversal of the ZAHARA3 study; whether subclinical congenital heart disease occurs in women who deliver prematurely for unknown reason. The biosamples taken during and after delivery will be used to determine…
- To identify the causes of inflammation of adipose tissue, liver and blood leukocytes by focusing on the contribution of the gut microbiota taking into account dietary habits and genetic background.- To assess the influence of inflammation of…
Primary objective:* To investigate the consequences of (recurrent) hypoglycaemia on inflammatory responsesSecondary objectives:* To study the atherogenic consequences of (recurrent) hypoglycaemia* To study the molecular mechanisms involved in the…
To investigate the interrelatedness between clonal hematopoiesis of indeterminate potential (CHIP) and trained immunity.
To obtain human fibroblasts from extreme dyslipidemia patients or patients with premature atherosclerosis to study cholesterol metabolism.
The objective of this project is to study the effects of low levels of dietary AGEs in overweight subjects on insulin sensitivity, *-cell function, micro- and macrovascular function, and gut microbiota. The obtained insights can be used to attenuate…
Aim of the trial is to validate the TAXINOMISIS system for risk stratification of carotid artery stenotic disease.
The main objective of this study is to compare calcification promoting and inhibiting factors and their interactions in the serum of PXE patients and healthy controls. Secondary objectives (optional) are:1) to identify differences in cognitive…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with symptomatic SVDs, relative to controlsSecondary Objective(s): To establish how microvascular function relates to:• parenchymal lesion…
The primary outcome is to assess carotid artery plaque constitution in terms of intraplaque hemorrhage and plaque burden (thickness) as measured with 3T MRI in both hemophilia patients and control patients
to evaluate the anti-inflammatory effects of 3 months statin therapy on vessel wall inflammation by means of FDG PET/CT in patients with CKD
Primary objective: To investigate whether AS patients have increased signs of microvascular abnormalities of the retina, compared with healthy controls.Secondary objectives: to investigate:1. the peripheral microvascular function in AS patients,…
The main objective of this study is to compare the function and phenotype of bone marrow HSPC*s in AMI patients to those of healthy control subjects.
Primary Objective: To study arterial vessel wall abnormalities of the intracranial vessels (circle of Willis and its main branches and the moyamoya vessels) in patients with MMV in comparison with age- and sex-matched subjects without known…
1. To assess whether nocturnal hemodialysis and renal transplantation give less progression of arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;2. To identify the risk factors for arterial calcification in…
1. To identify a biomarker of hepatic DNL in different disease models of NAFLD. 2. To assess the cardiovascular risk profile in the different disease models of NAFLD.
The objective of this study is to find out if low plasma PPi levels are involved in PAD. A second aim is find other serum calcification inhibitors involved in PAD.
We aim to assess the association between (cardio-)vascular and hemodynamic factors in relation to cognitive function.
The objective is to study the possible effects of AGE/ALE reduction on vascular function as primary endpoint, insulin sensitivity, and adipokine levels in abdominally obese subjects. We will investigate the following parameters:1) Micro- and…