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Flow augmentation study

Primary Objective: The primary objective of this study is to identify whether the Geko system can augment flow compared to IPCS in post-thrombotic limbs before after stenting.(group 1) In group 2 we want to identify whether the Geko with occluded…

Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in The Netherlands for Late Arrivals: MR CLEAN LATE

To assess the effect of IAT compared with best medical treatment in patients with AIS caused by an intracranial large vessel occlusion of the anterior circulation, who have moderate to good collaterals and who can be treated between 6 and 24 hours…

Multicenter Randomized CLinical trial of endovascular treatment for acute ischemic stroke in the Netherlands. The effect of periprocedural MEDication: heparin, antiplatelet agents, both or neither.

To assess the effect of acetylsalicylic acid (ASA) and unfractionated heparin, alone, or in combination, in patients with AIS, who undergo IAT for a confirmed intracranial anterior circulation occlusion.

Long-term follow-up MR CLEAN-NO IV: evaluation of long-term outcomes after acute ischemic stroke.

The aim of this study is to assess the long-term outcomes (up to 36 months) and costs of stroke after EVT treatment, including direct EVT and IVT followed by EVT.

Carotid Artery ImPlant for Trapping UpstReam Emboli
(CAPTURE) for Preventing Stroke in Atrial Fibrillation
Patients

To assess the safety, feasibility, and tolerability of the Vine* Embolic Protection System and implantation procedure in atrial fibrillation (AF) patients at high stroke risk who are unsuitable for oral anti-coagulants (OAC).

Apixaban for the treatment of venous thromboembolism in patients with cancer: a prospective randomized open blinded end-point (probe) study - the Caravaggio study

The aim of this study is to assess whether oral apixaban in non-inferior to the subcutaneous LMWH dalteparin for the treatment of newly diagnosed proximal DVT and/or PE in patients with cancer.

Assessment of the WATCHMAN TM Device in Patients Unsuitable for Oral Anticoagulation (ASAP-TOO)

The primary objective of this study is to establish the safety and effectiveness of the WATCHMAN TM Left Atrial Appendage Closure (LAAC) Device including the post-implant medication regimen for subjects with non-valvular atrial fibrillation who are…

Influence of anticoagulant therapy on platelet mRNA profiling

To evaluate the influence of anticoagulant treatment on the platelet mRNA profile in patients in whom anticoagulation is initiated.

HOw feaR affects platelet aggRegability in healthy vOlunteeRs * a randomized cross-over study

To explore if acute fear, induced by watching a horrifying movie, influences platelet aggregability in healthy volunteers.

BLO2D Unlimited
The effect of repeated exercise at high altitude on blood coagulation

To investigate the effect of monitored strenuous exercise at high altitude on blood coagulation, more specifically on thrombin generation, platelet function and fibrinolysis.

Characterization of blood coagulation in cancer patients for the development of an algorithm to predict the risk of thrombosis.

Primary Objective: The primary objective of this study is to measure a broad panel of coagulation tests in a cohort of cancer patients to determine whether one or a combination of these tests is able to predict the risk of thrombotic events in the…

A THREE MONTH PROSPECTIVE OPEN LABEL STUDY OF THERAPY WITH FRAGMIN® (DALTEPARIN SODIUM INJECTION) IN CHILDREN WITH VENOUS THROMBOEMBOLISM WITH OR WITHOUT MALIGNANCIES.

The primary objective of this study is to:* To determine the PD profiles for treatment doses of dalteparin in pediatric subjects of different ages with or without cancer and VTE, using anti-Xa levels and a population PD analysis methodology;* To…

Hospitalization or Outpatient ManagEment of patients with Pulmonary Embolism: a randomized controlled trial - HOME-PE

Main safety objective: To demonstrate, in normotensive PE patients, that a strategy based on the HESTIA rule compared to a strategy based on the simplified PESI score is at least as safe as regards the 30-day-rate of adverse events (recurrent VTE,…

Phase 1 trial of mutant proUK: HisproUK

The primary objective of the study is:* To evaluate the overall safety and tolerability related to systemic plasminogen activation of single doses of HisproUK (part 1) and sequential administration of tPA and HisproUK (part 2)The secondary…