50 results
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
PrimaryImproved woundhealing in 30 days in patients with an open revascularisation of the lower extremities after treatment with 4 dosages of 2 grams ascorbic acid on 4 consecutive days. (First dosage 1 hour preoperative)SecondaryWith preoperative…
The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are present in children of different weight categories and whether these are age dependent. Also differences * and relationships between * vascular…
Determining the role of duplex ultrasound in patients with a clinical suspicion for temporal arteritis.Determing the sensitivity, specificity, negative predictive value and positive predictive value of duplex ultrasound in patients with a clinical…
1. The primary objective is to assess the effects of four 250 mg PC-mAB (also referred to as "3G10") once monthly intravenous injections on monocyte function ex vivo. The secondary objectives are to:1. assess the functional effects of 3G10…
Aim of the study is to determine the microvascular function in type 1 diabetes patients with concomitant celiac disease
This study aims to investigate the sensitivity and specificity of the history and physical examination for the diagnosis of giant cell arteritis, compared with the superficial temporal artery biopsy, and get more insight into the positive and…
To determine the effect of a single red blood cell transfusion on the microcirculation.
The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
The primary objectives of the study are to assess the prevalence of large artery inflammation in patients with temporal arteritis or an unexplained inflamatory response and the diagnostic utility of 18FDG-PET/CT in patients with an unexplained…
The aim of the current study proposal is to test the validity of a decision tree focused on skin autofluorescence, and based on the results described above, as a detection tool for diabetes and impaired glucose tolerance in 2 new cohorts, one in an…
This study is designed to determine the vessel wall inflammation in patients with extreme levels of one traditional risk factor.
This research aims the usefullness of duplex mapping in systemic giant cell vasculitis. In determing the diagnosis, the duplex will be compared with the current gold standard, the 18F-FDG PET-CT, looking at the sensitivity and specificity of the…
The aim of this project is to assess whether 4D-CTA can generate 3D cranial image data sets with sufficient spatial and temporal resolution to enable its use as a diagnostic tool in cerebrovascular pathology and physiology such as arteriovenous…
The primary objective in this observational study is to determine microcirculatory profile in preterm and term neonates. We would like to determine how the microcirculation changes in time during the phase of adaptation and correlate inter- and…
The principal aim of this study is to examine whether glycocalyx volume, as estimated by SDF-imaging, is associated with cardiovascular risk as estimated by conventional risk scores.
The aim of this study is to compare the 16S PCR technique with standard bacterial cultures of infected vascular grafts, mycotic aneurysms and non-infected aortic aneurysms.
Are AGEs, as a predictor of increased risk for cardiometabolic syndrome, increased in shift workers?
The aim of this study is to investigate skin AGEs, as a predictor of increased risk for cardiometabolic syndrome, in a shift work population as compared to non-shift workers to assess its potential as an early assessment of the actual risk for…
Effect of SCS on CBF