37 results
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
Determining the role of duplex ultrasound in patients with a clinical suspicion for temporal arteritis.Determing the sensitivity, specificity, negative predictive value and positive predictive value of duplex ultrasound in patients with a clinical…
This study aims to investigate the sensitivity and specificity of the history and physical examination for the diagnosis of giant cell arteritis, compared with the superficial temporal artery biopsy, and get more insight into the positive and…
To determine the effect of a single red blood cell transfusion on the microcirculation.
The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
The primary objectives of the study are to assess the prevalence of large artery inflammation in patients with temporal arteritis or an unexplained inflamatory response and the diagnostic utility of 18FDG-PET/CT in patients with an unexplained…
The aim of the current study proposal is to test the validity of a decision tree focused on skin autofluorescence, and based on the results described above, as a detection tool for diabetes and impaired glucose tolerance in 2 new cohorts, one in an…
This study is designed to determine the vessel wall inflammation in patients with extreme levels of one traditional risk factor.
This research aims the usefullness of duplex mapping in systemic giant cell vasculitis. In determing the diagnosis, the duplex will be compared with the current gold standard, the 18F-FDG PET-CT, looking at the sensitivity and specificity of the…
The aim of this project is to assess whether 4D-CTA can generate 3D cranial image data sets with sufficient spatial and temporal resolution to enable its use as a diagnostic tool in cerebrovascular pathology and physiology such as arteriovenous…
The primary objective in this observational study is to determine microcirculatory profile in preterm and term neonates. We would like to determine how the microcirculation changes in time during the phase of adaptation and correlate inter- and…
The principal aim of this study is to examine whether glycocalyx volume, as estimated by SDF-imaging, is associated with cardiovascular risk as estimated by conventional risk scores.
The aim of this study is to compare the 16S PCR technique with standard bacterial cultures of infected vascular grafts, mycotic aneurysms and non-infected aortic aneurysms.
The objective of this pilot study is to provide information about the usefulness of NIRS in the study of patients with JDM in the test configuration as described in the protocol. For this purpose, the microvascular oxygenation and hemodynamics in…
This study concerns a research that is aimed to investigate the prevalence of the metabolic syndrome in a group of patients known with ANCA-associated vaculitis. Hereby we will compare the presence of the metabolic syndrome between an ANCA-…
What is the base-line StO2 reference value in intestinal stoma's. ? Is NIRS a reliable detector of intestinal ischamia ? What is the influence of filling-status on StO2 in the stoma and sublingually ? What is the influence of NTG on StO2 in the…
Primary objectives1. To investigate prospectively the prevalence of cardiovascular damage due to cancer treatment and it*s change over time.2. To investigate markers of early and late toxicity of cardiovascular damage due to cardiotoxic treatment.…
Our working hypothesis is based on the interplay between vascular dysregulation, neuropathological alterations and decline in AD brain function. In the latent phase vascular dysregulation is already apparent when patients are asymptomatic.…
The main aim of the study is therefore to examine mu wave activity during observation, execution of movements and during movement imagery in comparison to a passive resting state and active relaxation condition in stroke patients and matched healthy…