181 results
to explore the effect of sodium intake on the coffee-induced increase in blood pressure
To test the efficacy of renal sympathetic denervation therapy with a special focus on preservation of renal allograft function.
Primary:To assess after administration of a single oral dose of 75 mg S 38844 containing 55 *Ci (2.035 MBq) of [14C]-S 38844:* The excretion balance of total radioactivity;* The pharmacokinetics of total radioactivity in blood and plasma;* The…
We will enable CEUS measurements of forearm skeletal muscle and determine the intra-observer and day-to-day variability in CEUS measurements.
The purpose of this clinical investigation is to verify the efficacy and safety of the CVRx Neo Baroreflex Activation Therapy System in subjects who qualify for the implantation for a Baroreflex Activation Therapy System.
A study will be conducted to investigate whether screening for PE and growth restriction not associated with PE in the Dutch setting is feasible.
Is recurrent miscarriage an independent risk factor for an increased cardiovascular risk?
In the present project we aim to develop a first working platform for interactive, home-based blood pressure screening and monitoring by using internet and smartphone technology in middle-aged offspring of patients with dementia.
To determine the effect of bevacizumab on vascular tone in humans by using plethysmography.
To evaluate whether cognitive function of formerly preeclamptics is diminished and correlated with dynamic cerebrovascular control properties using non-invasive measuring techniques (dynamic cerebral autoregulation, neurovascular coupling). Question…
Primary objective1.To determine the characteristics, frequency and severity of vascular, metabolic and hormonal side effects of angiogenesis inhibitors and EGFR inhibitors.Secondary objectives1.To investigate if steroid profile, indol profile,…
In this study, we will assess whether healthy and hypertensive subjects with high-normal serum CK display greater salt retention and vascular contractility, compared to those with low-normal serum CK.
To demonstrate that after a reduction in systolic blood pressure between 20 and 80mmHg within 3 months to reach a target of 140 mmHg, cerebral blood flow is not lower than prior to the start of treatment.
With a standardized approach in a population with difficult to treat hypertension we want to explore how frequenty PHA is a cause of hypertension and what the test characteristics of the aldosterone-renin ratio are. Additionally we want to…
Primary objective:• To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful pregnancy.Secondary…
Following the participants three more years will enable us to get a better overview of the consequences of the screening with regard to treatment, health, lifestyle modifications and illness perception with regard to obesity. Primary Objective: • To…
Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls.
To study the effects of physical training on vascular, endothelial and immunologic functioning in women with recurrent miscarriage; results are compared with women who have never been pregnant (nulligravid controls) and women who have a history of…
The results of this study will give better insights in the role of ADMA in the development of systemic endothelial dysfunction.
To investigate the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related target-organ damage (renal insufficiency and heart failure).