181 results
To study in two national cohorts of HSCT survivors, treated in different time periods, the prevalence and risk factors of metabolic syndrome, endothelial dysfunction (as a sign of vascular damage) and the clinical phenotypes of accelerated aging so…
This study has been transitioned to CTIS with ID 2023-504861-22-00 check the CTIS register for the current data. This study will assess the safety and tolerability of sotatercept in pediatric participants with PAH WHO Group 1 who receive PAH…
The primary objective of this study is to investigate how the vascular regulation is altered in the maternal as well as placental vasculature of women with pregnancy disorders (preeclampsia, pregnancy-induced hypertension, FGR, preterm birth,…
The trial will investigate the safety and tolerability of BI 685509 in patients with CSPH in compensated cirrhosis due to HBV, HCV and NASH with or without T2DM and the combination of BI 685509 and empagliflozin in patients with CSPH in compensated…
To assess the feasability of measuring placental perfusion by measuring the placental and uterine blood vessels and maternal haemodynamic function in women with singleton pregnancies between 14- and 16-weeks*gestational age.
To quantify fructose that escapes the portal circulation and appears in the systemic circulation, by measuring serum fructose using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) within 150 minutes following intake of…
To evaluate whether personalized antihypertensive treatment of mild to moderate gestational hypertension based on maternal hemodynamic profile leads to effective treatment of hypertension with better maternal and neonatal outcome compared to no…
The SPYRAL AFFIRM study will evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in a population of approximately 1300 renal denervation treated subjects with up to 36 months of follow-up, including several sub-…
To investigate the role of the immune and coagulation system on the progression of cerebral SVD
The objective of our study is to investigate whether application of the PreRisk calculator, based on the sFlt1/PlGF ratio,protein-to-creatinine ratio and gestational age, in patients with (suspected) PE can reduce the number and duration of…
In this study we aim to elucidate effects of dietary sodium intake on:1. Body weight and blood pressure2. Microcirculation by studying the capillary network during high and low sodium conditions.3. Adaptive and innate immune system by studying…
To investigate whether online mindfulness-based stress reduction (MBSR) therapy and an aerobe training intervention both leading to stress reduction and reduced circulatory risk in formerly preeclamptic women with increased mental stress levels…
To provide continuing open-label treatment with bardoxolone methyl as part of this extended access program while collecting ongoing safety and tolerability data of bardoxolone methyl.
Primary objective:To determine BBB integrity and the interplay with microvessel function including PVS and CVR response to CO2 breathing challenge in sporadic and monogenic presentations of human SVDs.Secondary objective:To determine the…
Primary objective: To demonstrate pharmacokinetic comparability of 3D-printed sildenafil tablets and the originator sildenafil tablets following a single 20 mg dose in healthy adult subjects.Secondary objectives:• To describe the plasma…
In this study we want to investigate if there is a difference in exposure to losartan and perindopril between younger and elderly patients. Furthermore, the results will enable us to correlate detailed PK data with PD data, which can lead to a more…
The objective of this study is to compare OCT-A findings between five groups of non-glaucomatous subjects characterised respectively by a) low symptomatic, b) low asymptomatic, c) normal asymptomatic, d) untreated high asymptomatic, and e) treated…
To determine whether measuring drug levels combined with personalized feedback improves adherence and leads to a decrease in resistant hypertension after 12 months of follow-up.
The objective of this single arm interventional study is to determine if renal denervation performed in the distal main and first order branch renal arteries is as effective in reducing blood pressure as the procedural approach used in the SPYRAL…
In this study the primary objective is to investigate whether activation of TRPV1, TRPA1 and TRPM3 by selective channel agonists induces vasodilation in human dermal arteries. If the primary objective is achieved, the secondary objective is to…