102 results
The trial will compare two doses of BI 685509 (2 mg and 3 mg BID) with placebo, on top of standard of care, in patients with CSPH in compensated alcohol-related cirrhosis. The primary objective is to estimate the mean difference between treatment…
The trial will investigate the safety and tolerability of BI 685509 in patients with CSPH in compensated cirrhosis due to HBV, HCV and NASH with or without T2DM and the combination of BI 685509 and empagliflozin in patients with CSPH in compensated…
To evaluate the efficacy and dose-response relationship of XXB750 30 mg SC q4w, 60 mg SC q4w, 120 mg SC q4w, and 240 mg SC q4w compared to placebo in reducing the mean 24hr ambulatory systolic blood pressure (mean 24hr SBP) from baseline to Week 12.…
This study has been transitioned to CTIS with ID 2023-510257-42-01 check the CTIS register for the current data. Sodium-glucose cotransporter 2 (SGLT2) inhibitors lead to a lowering of blood pressure and confer cardiovascular and renal protection in…
The SPYRAL AFFIRM study will evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in a population of approximately 1300 renal denervation treated subjects with up to 36 months of follow-up, including several sub-…
The objective is to investigate whether application of a stepwise work-up strategy in primary care patients with uncontrolled hypertension results in better blood pressure control in a cost-effective manner.
To provide continuing open-label treatment with bardoxolone methyl as part of this extended access program while collecting ongoing safety and tolerability data of bardoxolone methyl.
Primary objective: To demonstrate pharmacokinetic comparability of 3D-printed sildenafil tablets and the originator sildenafil tablets following a single 20 mg dose in healthy adult subjects.Secondary objectives:• To describe the plasma…
In this study we want to investigate if there is a difference in exposure to losartan and perindopril between younger and elderly patients. Furthermore, the results will enable us to correlate detailed PK data with PD data, which can lead to a more…
The objective of this single arm interventional study is to determine if renal denervation performed in the distal main and first order branch renal arteries is as effective in reducing blood pressure as the procedural approach used in the SPYRAL…
The primary objective of the study is to demonstrate the BP lowering effect ofaprocitentan when added to standard-of-care in true resistant hypertension subjects.The secondary objectives of the study are• to demonstrate that the effect of…
Primary Objective: To compare the fetal/maternal ratio of nifedipine blood concentrations between pregnancies with and without hypertensive disorders, including preeclampsia.Secondary Objective: To compare predicted fetal/maternal drug ratios with…
The main objective of this effectiveness study is to test if intensive control (SBP *120 mmHg) decreases cerebral blood flow velocity compared to conventional targets (SBP<140-150 mmHg) in patients with CSVD and hypertension. Secondary…
To determine the safety of the MobiusHD System and the efficacy of the MobiusHD device in lowering mean systolic 24-hour ambulatory blood pressure in subjects with resistant hypertension. The hypothesis is that mean systolic 24-hour ambulatory blood…
To determine the safety of the MobiusHD System and the efficacy of the MobiusHD device in lowering mean systolic 24-hour ambulatory blood pressure in subjects with resistant hypertension. The hypothesis is that mean systolic 24-hour ambulatory blood…
To evaluate the safety and effectiveness of the BackBeat Moderato system.
The objective of this study is to evaluate blood pressure response after renal denervation in patients with uncontrolled hypertension compared to a sham-controlled population, in the absence of antihypertensive medications. In this study, *…
The primary objective of this clinical trial is to obtain pilot safety and efficacy data on treatment of PAH patients by 6-MP. The secondary objective of this clfnical trial is to determine whether LEPs transcriptome analysis will identify a subset…
The purpose of the study is to investigate how quickly and to what extent ACT-132577 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). ACT-132577 to be administered will be labeled…
The primary objective of this study is to determine whether daily oral supplementation of Vitamin K2 will slow down or arrest CAC-progression after 12 and 24 months in comparison to placebo in patients with established CAC. Secondary, we wish to…