69 results
1. Does mPAT directly impair vasoreactivity to insulin and acetylcholine ex vivo in arterioles obtained from muscle biopsy in lean and obese individuals?2. Is obesity in humans associated with the accumulation of mPAT and an inflammatory mPAT…
The researchquestion of this study:Is there an association between the respiratory and cardiovascular system in early childhood? If there is an assocation, what are its determinants?
We will enable CEUS measurements of forearm skeletal muscle and determine the intra-observer and day-to-day variability in CEUS measurements.
Is recurrent miscarriage an independent risk factor for an increased cardiovascular risk?
Primary objective1.To determine the characteristics, frequency and severity of vascular, metabolic and hormonal side effects of angiogenesis inhibitors and EGFR inhibitors.Secondary objectives1.To investigate if steroid profile, indol profile,…
Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ. Secondary objectives: to compare changes in the following parameters in…
In this study, we will assess whether healthy and hypertensive subjects with high-normal serum CK display greater salt retention and vascular contractility, compared to those with low-normal serum CK.
Main study:1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients.2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced mi-crovascular effects in…
Primary objective:• To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful pregnancy.Secondary…
Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls.
To study the effects of physical training on vascular, endothelial and immunologic functioning in women with recurrent miscarriage; results are compared with women who have never been pregnant (nulligravid controls) and women who have a history of…
To investigate the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related target-organ damage (renal insufficiency and heart failure).
We will investigate how video microscopy compares to CEUS in its assessment of insulin-mediated vasoreactivity.
The goal of this study is examining the acute effects of insulin on microcirculation in hypertensive insulinresistant subjects and investigate if angiotensine II influences these effects. Amendement: The goal of the amendement is to exame the…
The aim of the study is:- To find simple clinical and/or laboratory parameters to predict the development of hypertension during treatment with the tyrosine kinase inhibitor Sunitinib. If such parameters are present it will be evaluated…
To determine the underlying mechanisms responsible for thiazide-induced hyponatraemia and to identify (elderly) patients who are at risk of this potentially life-threatening complication.
To study etnic differences in contractillity of the smooth muscle and to investigate the role of CK in this proces.
In the current study we want to evaluate the microcirculatory glyccalyx in patients presenting with malignant hypertension and relate this to patients with severe hypertension. Microcirculation is assessed using SDF imaging, oxygen supply using NIRS…
To investigate the difference between two meals (high in protein vs. high in carbohydrates) on the endothelial function?
We aim to study the vasoactive effects of Acetylcholine (NO dependent) in hypertensive patients and normotensive participants. Second, the correlation between the vasoreactivity of Acetylcholine and Angiotensin II will be studied. Third, the…