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Autonomic function in Alzheimer: assessment using tilt-table testing

The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…

Vascular Phenotypes in a Geriatric Population

The objective of this study is to relate different vascular phenotypes, based on macro- and microvascular measurements, to changes in cognitive and physical functioning in a geriatric population.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH

The objective of this study is to evaluate the efficacy and safety of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) at 24 weeks in adults with PAH.

A Phase 3, Randomized, Double-blind, Placebo controlled Study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate- and High-risk PAH Patients

The objective of this study is to evaluate the effects of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) on time to clinical worsening (TTCW) in participants who are newly diagnosed with PAH and are…

A First in Humans Study of Safety and Feasibility of baroloop:
The baroloop Study

The primary objectives are to assess the safety and feasibility ofthe baroloop device for the treatment of subjects with hypertension (HTN). The secondary objective is to document the effect of the baroloop device on the blood pressure and quality…

Randomised, double-blind, placebo-controlled and parallel group
trial to investigate the effects of two doses (up-titration to a fixed
dose regimen) of oral BI 685509 on portal hypertension after 24
weeks treatment in patients with clinically significant portal
hypertension (CSPH) in compensated cirrhosis

The trial will compare two doses of BI 685509 (2 mg and 3 mg BID) with placebo, on top of standard of care, in patients with CSPH in compensated alcohol-related cirrhosis. The primary objective is to estimate the mean difference between treatment…

Stress reduction in formerly preeclamptic women; sofa or sports?

To investigate whether online mindfulness-based stress reduction (MBSR) therapy and an aerobe training intervention both leading to stress reduction and reduced circulatory risk in formerly preeclamptic women with increased mental stress levels…

A randomized, open-label, single dose two-way cross-over pharmacokinetic study of 3D-printed sildenafil tablets compared to the originator sildenafil tablets in healthy adults

Primary objective: To demonstrate pharmacokinetic comparability of 3D-printed sildenafil tablets and the originator sildenafil tablets following a single 20 mg dose in healthy adult subjects.Secondary objectives:• To describe the plasma…