20 results
1) to investigate whether hypertensive patients with WMLs decline more strongly in cognitive function than hypertensive patients without WMLs in a 4-year time period. 2) to identify predictors for cognitive dysfunction in hypertension/SVD patients.
Primary objective:To assess and compare the effects of aliskiren/amlodipine and amlodipine on pedal edema after 4 weeks of treatment as measured by ankle foot volume (AFV) (water displacement method) in patients with mild to moderate hypertension.…
Primary Objective1. The main objective of this study is to demonstrate that OM/AML/HCTZ triple combinations are more efficacious in lowering SeDBP than corresponding dual combinations of OM/AML after 10 weeks of double blind treatment.Secondary…
For pregnant women with non-severe non-proteinuric maternal hypertension at 14-33 weeks, will *less tight* control (target dBP of 100mmHg) vs. *tight* control (target dBP of 85mmHg) increase or decrease the likelihood of pregnancy loss or neonatal…
Primary: Period II (Week 8 to Week 16)1. To demonstrate the additional antihypertensive efficacy for seated diastolic blood pressure (SeDBP) gained by adding HCTZ 12.5 or 25 mg to the treatment regimen in subjects with moderate to severe HTN not…
The present study has 2 primary objectives: 1: The first aim of the present study is to explore early detection possibilities using plasma hemopexin activity and plasma ATP levels in cohorts of pregnant women in a time course manner (experiment 1).…
1. Does mPAT directly impair vasoreactivity to insulin and acetylcholine ex vivo in arterioles obtained from muscle biopsy in lean and obese individuals?2. Is obesity in humans associated with the accumulation of mPAT and an inflammatory mPAT…
To determine the effect of bevacizumab on vascular tone in humans by using plethysmography.
To evaluate whether cognitive function of formerly preeclamptics is diminished and correlated with dynamic cerebrovascular control properties using non-invasive measuring techniques (dynamic cerebral autoregulation, neurovascular coupling). Question…
To demonstrate that after a reduction in systolic blood pressure between 20 and 80mmHg within 3 months to reach a target of 140 mmHg, cerebral blood flow is not lower than prior to the start of treatment.
Following the participants three more years will enable us to get a better overview of the consequences of the screening with regard to treatment, health, lifestyle modifications and illness perception with regard to obesity. Primary Objective: • To…
Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls.
To study the effects of physical training on vascular, endothelial and immunologic functioning in women with recurrent miscarriage; results are compared with women who have never been pregnant (nulligravid controls) and women who have a history of…
To investigate the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related target-organ damage (renal insufficiency and heart failure).
Objective: To determine the effect of a device slowing breathing (Resperate©) on office systolic blood pressure (SBP) in diabetic patients with treated hypertension with moderate BP control.
The overall aim of the study is to evaluate the effect of CVPE in Afro-Surinamese and Ghanaian who are treated for HTN in general practice and who have an uncontrolled blood pressure. (systolic BP > 140 mmHG and/or diastolic BP > 90…
We will investigate how video microscopy compares to CEUS in its assessment of insulin-mediated vasoreactivity.
The objective of the study is to investigate whether the Out-Of-Office BPM device of Microlife, the WatchBP O3, is comparable to the Spacelabs 90217 device at 24h BP measurement. Secondary objectives: To investigate whether the implemented features…
To determine the effect of bevacizumab on the vasodilator response of acetylcholine in humans by using plethysmography.To determine the effect of bevacizumab on the vasodilator respons of nitroprusside in humans by using plethysmography
The primary objective of this study is to determine whether daily oral supplementation of Vitamin K2 will slow down or arrest CAC-progression after 12 and 24 months in comparison to placebo in patients with established CAC. Secondary, we wish to…