25 results
Goal of our study is to compare the CO measuments by the Oesophageal Doppler Monitor (ODM, Cardio Q) with the TPTD technique (PiCCO) and to determine reliability of the ODM in absolute CO values and as a trend monitor. A validation study comparing…
Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.
The primary objective of this study is to determine whether the Impella cVAD device vs. IABP therapy leads to a higher 30 day survival rate in shock STEMI patients in the setting of primary PCI.
To study dose-dependent hemodynamic and microcirculatory changes during oxygen supply in mechanically ventilated ICU patients.
To detect incipient central hypovolemia preceding symptomatic cerebral hypoperfusion by machine learning models trained on realistic physiological models.
The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…
Primary objective: To determine the effect of hyperbilirubinemia on systemic activation of the innate immune response induced by a lipopolysaccharide (LPS) challenge. Secondary Objective(s): - To determine if hyperbilirubinemia shifts the pro-anti…
To evaluate the effect of age of transfused erythrocytes on expression of *eat me* signals on erythrocytes in several critically ill patient populations (septic and non-septic patients) and to correlate these signals with parameters of impaired…
To assess the effectiveness of an additional cardiovascular assessment and intervention to a multidisciplinary falls-intervention.
To compare neonatal mortality and short-term (advanced MRI indices of structural brain injury at 40 weeks* GA) and long-term neurodevelopmental outcomes (Bayley scales of infant development III [BSID-III] at 24 months) between two groups of very…
The aim of the present study is to investigate cerebral vasoreactivity in response to lower body negative pressure in young and elderly healthy men, as a measure of cerebral autoregulatory responsiveness.
To investigate if norepinephrine is safe and effective in increasing blood pressure and systemic blood flow in premature and full-term neonates with shock and/or hypotension.
The main objective of the study is to determine the diagnostic and prognostic added value of careful history taking and Nexfin in the initial evaluation of (pre-) syncope patients in the ED and the follow-up period. The secondary objective is to…
To compare the accuracy of the above-mentioned methods in patients admitted to the ward or intensive care unit in estimating CVP and to investigate the correlation between the different methods.
We aim to investigate the clinical benefit of cytokine adsorption on post-cardiothoracic surgery vasoplegic syndrome.
The primary objective of this study is to evaluate the personalized hemodynamic resuscitation protocol, guided by the Baxter Starling, for sepsis patients within the first six hours after admission to the emergency department, in comparison to the…
In this study, we aim to investigate the postoperative time course of microcirculatory parameters in patients admitted to the ICU after cardiothoracic surgery with and without circulatory shock. Secondary objectives:* To study the postoperative time…
To determine the effect of SaO2 and PaO2 levels on mitoPO2 and markers of oxygen delivery and consumption in healthy human volunteers.
The primary objective of this study is to determine the accuracy of the delta PCO2 (PaCO2-tcPCO2) and delta PO2 (tcPO2 -cPO2) levels for the detection of sepsis. The secondary aims are to determine the factors that influence delta PCO2 and delta PO2…
The primary aim of the study is to determine the incidence of perioperative hypovolemia in the elderly patient scheduled for major surgery, and how this relates to postoperative complications.