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A randomized, double-blind, placebo-controlled phase IIIa study of bIAP, an anti-inflammatory moiety, in patients undergoing combined aortic valve replacement and coronary artery bypass grafting.

Primary Objective:The objective of this study is to determine the efficacy of bIAP as a prophylactic agent against inflammation-mediated complications from more invasive cardiac surgery, aortic valve surgery and CABG with cardiopulmonary-bypass time…

Prevention Decline in Older Invasive Cardiac Surgery Patients

Study question and objective At this stage of developement of the multicomponent is intervention it is unclear whether the intervention is feasible in practice. Therefore the question: Is this multicomponent preadmission intervention feasible in…

The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial. A prospective, randomised, double blind, factorial trial testing whether aspirin, tranexamic acid, or both, can reduce mortality and/or major morbidity after elective coronary artery surgery.

Should low-dose aspirin be continued up until the day of CABG or OPCAB surgery?Should TxA be used for all at-risk CABG or OPCAB surgery?

Postoperative Pericardial Flush, to evaluate the effects of pericardial flush with a crystalloid on blood loss after valvular surgery and correction for CHD.

Primary objective: To determine whether postoperative pericardial flush with a crystalloid can reduce postoperative blood loss by effectively removing contaminated pericardial blood after valvular surgery and correction for CHD. The primary…

Pre-operative treatment with Erythropoietin and iron supplement for prevention of perioperative blood transfusion in cardiac surgery

Primary objective: To determine the reduction of number of patients who receive blood transfusion perioperatively in the group pre-treated with erythropoietin and iron supplement compared to the control patients.

Efficacy and safety of Haemocomplettan® P in patients experiencing microvascular bleeding while undergoing elective complex cardiac surgery

To determine whether fibrinogen concentrate infusion reduces perioperative blood loss and transfusion in patient experiencing clinically relevant microvascular bleeding during elective complex cardiac surgery and to determine whether its use is safe…

A clinical study to investigate the molecular effects of remote ischemic preconditioning in the myocardium of CABG patients with or without diabetes mellitus

The aim of this clinical study is to investigate whether remote ischemic preconditioining induces an activation or phosphorylation of signalling pathway molecules (MAPK) in myocardium in patients undergoing coronary artery bypass graft (CABG)…

Does have autologous blood withdrawal pre-operative with and without sequestration, effect on the usage of allogeneic bloodproducts during and after heartsurgery.

When it is possible to prove that there is a significant difference between the sequestration group and the other two groups, it also will be possible for patients with a smaller body surface to donate autologous blood and also this group will need…

Do washed irradiated red blood cells with a balanced solution improve the quality of the priming in cardiopulmonary bypass for neonates and infants?

Improve the quality of red blood cells used for cardiopulmonary bypass for neonates and infants with a bodyweight smaller then 10 Kg.

Catheter ablation versus Amiodarone to prevent future shock episodes in patients with a defibrillator and a history of a myocardial infarction.

The main objective of this study is to compare the occurrence of next ICD shock therapy for VT or VF in patients with hospital presentation for an ICD shock therapy for VT or VF, with a history of a myocardial infarction, between patients randomized…

A clinical study on the effect of Remote Ischemic Conditioning on atrial fibrillation and Outcome after coronary artery bypass grafting (RICO-trial)

The objective of this trial is to investigate whether remote ischemic preconditioning or remote ischemic postconditioning improves clinical outcome after coronary artery bypass grafting surgery, as measured by the incidence of postoperative atrial…

The Cardio Thoracic Harness

The objective of this study is to get insight in the effect of the Cardio Thoracic Harness for men and the Cardio thoracic bra for women. The harness and the bra possibly have an important role in pain management. The producer of the harness and the…

Autologous Platelet-Leukocyte Gel Therapy during sternum closure in cardiac surgery patients at risk for post-operative infection.

To investigate whether application of APLG will lead to reduction in: 1) sternal wound infections 2) vessel harvest site infections 3) postoperative blood loss 4) postoperative pain

The effect of two different heart-lung machines, Twin-Pulse Life Support and standard used heart-lung machine, on the systemic inflammation and pattern of microvascular blood flow. A prospective randomised clinical trial.

Analysis of the effects of the Twin-Pulse Life Support on on the systemic inflammatory response and the effect on microvascular blood flow in ocmparison to standard used Extracorporeal Circuit Device

Comparison of Biolimus Eluted from a Erodable Stent Coating with Bare-metal Stents in Acute ST-elevation Myocardial Infarction & In Vivo 3-Vessel Assessment of Time-Related Changes of Culprit and Non-Culprit Lessions by Grayscale IVUS, IVUS-VH and OCT in Acute Myocardial Infarction.

To establish superiority of the biolimus-eluting (BiomatrixTM) stent compared with an otherwise identical bare-metal stent (GazelleTM) in acute ST-segment elevation myocardial infarction (STEMI) in terms of the composite endpoint of cardiac death,…

Organ protection by noble gases * A clinical study to investigate Helium induced Pre- and Postconditioning in patients undergoing coronary artery bypass surgery.

The aim of this clinical study is to investigate whether the non-anaesthetic noble gas helium induces preconditioning (PreC) and postconditioning (PostC) in patients undergoing coronary artery bypass graft (CABG) surgery

The Impact of glutamine suppletion on outcome in patients undergoing high-risk cardiothoracic surgery.

Aim of the study is to assess the effects of supplemental parenteral L-alanyl-L-glutamine treatment on infectious, cardiac, cerebral, pulmonary and gastro-intestinal morbidity during the ICU- (Intensive Care Unit) and hospital stay in patients after…

The Real-World Endeavor Resolute versus Xience V Drug-Eluting Stent Study in Twente

Primary research questions:* To investigate whether the clinical outcome following the randomized implantation of the Endeavor Resolute® versus XIENCE V® drug-eluting stent is similar, as assessed in a non-inferiority setting by comparing target-…

Preserved platelet function during cardiopulmonary bypass with aprotinin in dual antiplatelet therapy.

Primary objectiveTo determine whether aprotinin can reverse the increased postoperative blood loss, induced by dual anti-platelet therapy in elective non-complex cardiac surgery.Secondary objectiveTo determine whether aprotinin reduces transfusion…

PREVENTION OF VASOPLEGIA WITH THE USE OF CYTOSORB

To test the efficacy and cost-effectiveness of using CytoSorb in preventing vasoplegia in patients with heart failure undergoing cardiac surgery on CPB.