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A PHASE III, RANDOMISED CONTROLLED TRIAL ASSESSING THE VALUE OF INDOCYANINE GREEN IN THE LEAKAGE RATE OF COLORECTAL ANASTOMOSES

Primary Objective: To compare the difference in clinically relevant AL after 90 days between perfusion assessment with ICG and standard surgery in colorectal anastomoses.Secondary Objective(s): 1. Change in surgical plan will be assessed within each…

Multicenter, open-label, controlled, parallel arms clinical study on the performance of SGM-101, a fluorochrome-labeled anti-carcino-embryonic antigen (CEA) monoclonal antibody, for locally advanced or recurrent rectal cancer patients undergoing curative surgery.

This study has been transitioned to CTIS with ID 2024-510768-21-00 check the CTIS register for the current data. This study aims to investigate if fluorescence guided surgery performed with SGM-101 can improve R0 resection rates and allows to find…

Second and third look laparoscopy in pT4 colon cancer patients for early detection of peritoneal metastases; the COLOPEC 2 randomized multicentre trial.

The primary aim of this study is to determine the added value of third look DLS to detect PM at a clinically occult stage following a negative second look DLS.

Feasibility of laser speckle contrast imaging using the bowel perfusion assessment tool Lapvas-Imaging

The overall objective of this study is to determine whether the use of additional Lapvas-imaging derived visual feedback might influence the choice of surgeons for the optimal location of the anastomosis.

Intra-operative Pancreatoscopy in Patients with Intraductal Papillary Mucinous Neoplasm (IPMN)

1. To demonstrate the added value of intraoperative pancreatoscopy in patients undergoing partial pancreatic resection for the treatment of Intraductal Papillary Mucinous Neoplasm (IPMN) as it pertains to detection of discontinuous (skip) lesions in…

Preoperative predictors of weight loss and improved metabolic health after bariatric surgery

Primary ObjectiveTo validate biomarkers of response to bariatric surgery and to develop algorithms, which combine these variables, to predict individual responses. Secondary Objectives* To establish the predictive value of selected preoperative…

ULTRA-ERAS: discharge after 24hours after colorectal surgery, a pilot study

The aim of the study is to assess if hospitalization can be reduced with the use of an early discharge protocol, named *ULTRA-ERAS*, in combination with tele monitoring in patients in elective colorectal surgery

Effect of a banded extended pouch in aRoux-en-Y gastric bypass

To investigate the effect of a banded-extended RYGB on weightloss and weigtregain on the long term.

Safety and feasibility of CT-guided percutaneous radionuclide therapy with the OncoSil* device in patients with non-progressive locally advanced pancreatic cancer (PANCOSIL): an open-label, single-arm phase 1-2 feasibility study

To assess the safety and feasibility of percutaneous CT-or ultrasound-guided RNT using the Oncosil* device in patients with non-progressive LAPC after induction chemotherapy treatment.

Multi-Interventional program for prevention and early Management of Anastomotic leakage
after total mesorectal excision in Rectal cancer patIents, IMARI-trial

To increase the one year anastomotic integrity rate in patients undergoing total mesorectal excision (TME) for rectal cancer by the routine and quality controlled implementation of a multi-interventional program, which includes:1. MBP with oral…

Hypoglycemia in post-bariatric vs. non-bariatric pregnancy: incidence and effects on fetal growth

Determine the number of hypoglycemic events (fasting and postprandial) during post-bariatric pregnancies compared to non-bariatric pregnancies (with obese and healthy BMI) using continuous glucose monitoring and its effects on fetal growth.

Sentinel node and organ sparing surgery in stage I colon carcinoma (SENTRY trial)

The aim of this study is to reduce the need for colectomy and its* associated morbidity and mortality in patients with high-risk pT1 or low-risk pT2 colon carcinoma after endoscopic polypectomy by performing a (robot-assisted) laparoscopic wedge…

A Pilot Study into the Use of Intraoperative Indocyanine Green Fluorescence Angiography in Young Infants & Neonates

This study aims to investigate whether the intraoperative use of indocyanine green fluorescence angiography (ICG-FA) is feasible and safe in neonates. Feasibility is therein defined as practically possible use of ICG-FA, resulting in clear and…

Optimising surgical anastomosis in ileocolic resection for Crohn's disease to reduce recurrent disease: A Randomized controlled trial comparing hand-sewn (END-TO-END or Kono-S) to stapled anastomosis (END2END study)

To understand if handsewn (end to end and Kono S side to side) anastomoses is superior to side to side stapled anastomosis after ileocolic resection for Crohn's disease with respect to endoscopic recurrence, gastrointestinal function and costs.

Influence of body weight on brain structure and function, the BARICO study, BAriatric surgery Rijnstate and RadboudUMC neuroImaging and Cognition in Obesity

To determine the effect of weight loss after bariatric surgery (BS) on different measures of cognition, brain function and structure investigated with various neuropsychological tests and studying various magnetic resonance imaging (MRI) parameters…

The effectiveness of adding Braun anastomosis to Standard Child reconstruction to reduce delayed gastric emptying after pancreatoduodenectomy (REMBRANDT): a multicenter randomized-controlled trial.

To assess the effectiveness of adding BE in reducing DGE in patients undergoing open pancreatoduodenectomy.

The stress hormone COrtisol and the development of MEtabolic Syndrome and Cardiovascular DIseases
Unravelling the cause(s) of hypercortisolism in obesity:
Investigating the influence of the liver, gut and immune system

Primary Objective: - To investigate the differences between hypercortisolistic patients with obesity and normocortisolistic patients with obesity, with respect to hepatic steatosis, immunological factors, and the gut microbioma in order to obtain…

Parent-child relationship, cognitive development and social-emotional functioning in children with intestinal failure;(PICASsO-study = Pediatric Intestinal failure: Cognitive And Social-emotional Outcomes)

(1) To assess parent-child attachment and interaction in a cohort of children and adolescents known with IF and (a history of) home PN dependence, and (2) to assess cognitive development and social-emotional functioning in these children.

Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy for Severe Obesity in Teenagers: a prospective cohort study.

To implement and assess the feasibility, efficacy and safety of bariatric surgery in adolescents with severe obesity together with a multidisciplinary care pathway around the procedure.

Pharmacokinetics of Paracetamol before and after Roux-en-Y gastric bypass

To assess the effect of a Roux-en-Y gastric bypass on the pharmacokinetics of a single oral dose of 1000 mg paracetamol before the surgery. within one month after the surgery and 6 months after the surgery.