5400 results
A pilot feasibility study (n=5) will be performed to evaluate the feasibility (logistics, timing) and safety of administering autologous tumor infiltrating lymphocytes (TIL) generated at the NKI-AVL infused in conjunction with systemic high-dose…
The main objective of the study is to monitor the factors effecting success of PDT, namely oxygen, photosensitizer concentration and, light dose before and during illumination to gather data that can be clinically correlated and later implemented.
Primary:To investigate the safety and tolerability of ascending doses of AZD3514 in patients with metastatic castration resistant prostate cancerSecondary: To assess the pharmacokinetics and preliminary anti-tumour activity of ascending doses of…
To establish the MaximumTolerated Dose, Dose Limiting Toxicities, and the safety profile of BMS-833923 administered in combination with cisplatin and capecitabine as first-line therapy. To describe preliminary evidence of tumor response as measured…
To investigate the relation between a known genetic variation in a set of selected genes involved in the recognition of microorganisms and inflammation and the frequency of respiratory tract infections in a group of children with DS.
To study the influence of hepatic impairment on plasma pharmacokinetic parameters of eribulin mesylate (E7389) following an IV administration.
The objective of the study (phase 2) is to evaluate the effectiveness of AMG 102 in combination with Mitoxantrone and Prednisone in previously treated subjects with castrate resistant prostate cancer.
Primary objectives: (1) Evaluation of the efficacy of vaccination against HPV 16, 18, 6 and 11 followed by local applications of imiquimod 5% cream compared to treatment with imiquimod alone for usual type VIN, (2) evaluation of the systemic and…
To measure the differences of DCE MR images between patients with and without local recurrent prostate cancer in the follow up after primary treatment.
Main objective is to examine the preliminary effectiveness of preoperative IMT high-intensity in patients undergoing oesophagus resection on postoperative pulmonary complications, inspiratory muscle strength/endurance and IC stay compared to…
Genetic analysis of the familial inheritance pattern of the COL3A1 2209G>A polymorphism.
To determine the maximum tolerated dose, dose limiting toxicity and recommended Phase 2 dose of BMS-753493 in subjects with advanced cancer.
Primary objective:To compare the specificity of multiple voxel MR spectroscopy with MRI.Secondary objective: To decrease the number of false positive diagnostic outcomes by using multiple-voxel MR-spectroscopy and therefore to reduce benign biopsies…
To determine the accuracy of 18F-FAZA-PET/CT and OE-MRI scan in detecting hypoxic regions within the tumor using histological markers.
The focus of this study is to get more insight in the pathophysiology of IUGR. The main goal is to investigate the applicability of STIC in determining fetal cardiac function in IUGR.
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Primary objective:* To determine the safety, tolerability, dose-limiting toxicities (DLT), maximum acceptable dose (MAD) and maximum tolerated dose (MTD) of CHR-2845 when administered orally to patients with advanced or treatment refractory…
Primary objectives of the study are to assess whether the administration of p53-SLP together with the local administration of IFNα is safe and able to induce a strong (directly ex-vivo detectable) p53-specific CD4+ T-cell response. Secondary…
Comparing fertilty of male galactosemia patients to a control group
To apply a novel blood assay to 150 patients undergoing a radical prostatectomy in order to assess whether this test can accurately identify indolent cancers and thereby prevent unnecessary treatments. To increase the accuracy of the flow cytometric…