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Unique epigenetic, transcriptional, metabolomic and proteomic characterization of the heart in cardiomyopathy patients

Using epigenetic, transcriptional, metabolomic and proteomic approaches in cardiac and skeletal muscle tissue, we want to reveal distinct biological pathways affected in ACM, DCM and PLN r14del cardiomyopathy.

Systematic Hospital-based Assessment of Rotterdam*s critically Ill children,
their Neurodevelopment and Growth

The main objective of this longitudinal study is to gain insight into the neurodevelopmental trajectories following neonatal critical illness, from the perinatal period to school-age compared to healthy controls. This insight may lead to the…

Quantifying Electropathology in Paediatric Patients with Congenital Heart Disease:
an intra-operative epicardial mapping study

To quantify the role of different abnormal loading conditions on atrial and ventricular electropathology in paediatric patients with CHD.

Better mechanistic understanding and risk stratification of ventricular arrhythmias through ECGI

Main objectiveTo identify and describe the electrophysiological substrate and triggers in patients with (an increased risk of) VTAs using ECGI, in order to improve understanding of arrhythmic mechanisms and use these for arrhythmia risk…

Evaluation of Lifetime participation in Intensive Top-level sports and Exercise

The general objective of ELITE is to establish a cardiac baseline of all NOC*NSF elite athletes, and to investigate changes in cardiac indices over time. The cardiac baseline includes cardiovascular screening using established diagnostic tools, as…

Two part (double-blind) inclisiran versus placebo [Year 1] followed by open-label inclisiran [Year 2] randomized multicentre study to evaluate safety, tolerability, and efficacy of inclisiran in adolescents (12 to less than 18 years) with homozygous familial hypercholesterolemia and elevated LDL-cholesterol (ORION-13)

Study CKJX839C12302 (ORION-13) is a pivotal phase III study designed to evaluate safety, tolerability, and efficacy of inclisiran in adolescents (aged 12 to <18 years) with HoFH and LDL-C >130 mg/dL (3.4 mmol/L). The use of inclisiran…

Two part (double-blind inclisiran versus placebo [Year 1] followed by open-label inclisiran [Year 2]) randomized multicenter study to evaluate safety, tolerability, and efficacy of inclisiran in adolescents (12 to less than 18 years) with heterozygous familial hypercholesterolemia and elevated LDL-cholesterol (ORION-16)

Study CKJX839C12301 (ORION-16) is a pivotal phase III study designed to evaluate safety, tolerability, and efficacy of inclisiran in adolescents (aged 12 to <18 years) with HeFH and LDL-C >130 mg/dL (3.4 mmol/L). The use of inclisiran…

Identifying disease specific pathways and modifiers in Phospholamban r14del cardiomyopathy

Our main objective is to identify disease modifiers in PLN r14del cardiomyopathy by studying patients are different ends of the PLN r14del cardiomyopathy disease spectrum with respect to differences in the circulating proteome and metabolome and in…

4D MR flow detection of hemodynamic predictors for aneurysm rupture

Relate aneurysm hemodynamics to aneurysm configuration and growth to obtain insight in the hemodynamic pathophysiology of aneurysm growth in order to improve prediction of aneurysm rupture.

Assessment of myocardial function, metabolism, and perFUSION in early and advanced disease stages of Hypertrophic CardioMyopathy: FUSION-HCM

In different stages of HCM:- To measure myocardial fatty acid oxidation, uptake and esterification- To measure myocardial glucose uptake en oxidation- To measure myocardial perfusion- To measure myocardial function- To measure volume parameters of…