161 results
In this study we will look at the blood levels of the study compound ziltivekimab. We will investigate how quickly and to what extent different compositions of ziltivekimab are absorbed, transported, and eliminated from the body. Ziltivekimab is not…
The primary objective is to test the hypothesis that S-ICD implant without DFT with PRAETORIAN Score is non-inferior to S-ICD implant with DFT with regard to first shock efficacy in spontaneous events. The secondary objective is to evaluate the…
Primary Objective: 1. To evaluate if chest CT can be withheld in post-embolization patients without or with a minimal pulmonary right-to-left shunt, based on:a. The evaluation of the grade of pulmonary RLS on TTCE after PAVM embolization in patients…
The main objective of this study is to assess the prevalence of PFO and RLS in patients with angina and documented coronary artery vasospasm.
The objective of this study is to identify novel genes causing congenital heart disease.
Our main objective is to identify disease modifiers in PLN r14del cardiomyopathy by studying patients are different ends of the PLN r14del cardiomyopathy disease spectrum with respect to differences in the circulating proteome and metabolome and in…
To determine whether 4D-flow CMR volume measurements are superior to 2D-PC CMR volume measurements by comparing the intra-class correlation between 2D-PC flow CMR stroke volume measurements in the MPA and multi-slice volumetric RV flow volume to the…
Primary objective of this trial is to investigate in a double blind randomized controlled trial in children undergoing open heart surgery if NO exposure during CPB reduces the postoperative duration of invasive mechanical ventilation (defined as…
Objective and Research QuestionsTo identify predictors of brain outcomes in HHT patients, we propose to leverage our multicenter network of HHT Centers to characterize comprehensive brain outcomes.Study Aims:Aim 1: We hypothesize that the presence…
The aim of the study is to obtain sufficient data on beneficial effects of Resveratrol on aortic aneurysm expansion rate and functional properties in patients with Marfan syndrome to justify a phase IIb or a phase III randomized trial.
Relate aneurysm hemodynamics to aneurysm configuration and growth to obtain insight in the hemodynamic pathophysiology of aneurysm growth in order to improve prediction of aneurysm rupture.
The objective of this study is to identify biomarkers predictive for the development of HCM in asymptomatic MYBPC3 mutation carriers and to identify prognostic biomarkers in mutation carriers in whom the disease has already been revealed. In order…
To test the hypothesis that supplementation with vitamin K2 in comparison to placebo (total duration of treatment: 18 months) will slow down aortic valve calcium metabolism (on18F-NaF PET/MRI) after 6 months in subjects with a bicuspid aortic valve…
Primary Objective: Measure QoL (VEINES QoL/Sym) change in patients with DVO at one year after PTA and stenting compared to conventional therapy (short class II elastic compressions stockings, exercise, lymph drainage therapy and the use of (pain)…
Primary Objective* To compare the effect of a 30-week course of mavacamten with placebo on clinical response comprising of exercise capacity and clinical symptoms in participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM)…
In different stages of HCM:- To measure myocardial fatty acid oxidation, uptake and esterification- To measure myocardial glucose uptake en oxidation- To measure myocardial perfusion- To measure myocardial function- To measure volume parameters of…
The primary objective is to evaluate the safety and effectiveness of the PULSTA TPV System for the treatment of congenital or acquired heart disease with pulmonary valve disease and to gain data that will lead to CE mark approval for the PULSTA TPV…
Primary :The primary objective is to evaluate the effect of inclisiran treatment on:* LDL-C levels at Day 510.* Time adjusted percent change in LDL-C levels from baseline after Day 90 up to Day 540 levelsSecondary:The secondary objectives are to…
To investigate whether the menstrual cycle influences diagnostics in patients with cardiovascular disease
This study will focus on the long-term outcome after surgical correction of several congenital heart defects in a non-selected cohort. The repetitive nature of this study will make it possible to analyze specific changes in cardiac function over…