31 results
The overall aim of the study is to improve diagnostic and therapeutic options for people with CF, especially in the context of young children and novel CFTR-targeting drugs. Primary Objective: 1. to demonstrate relations between CFTR genotype,…
Objectives: The primary objective is to establish whether expiratory VOC analysis by electronic nose and GC-MS can: Ia) discriminate between patients (CF, PCD) with and without an exacerbation and Ib) discriminate between different microbial species…
Primary objective: to evaluate the image quality between the two protocols using Signal to Noise Ratio (SNR) measurements Secondary objectives: 1) test if measurements of lung volume and central airways dimensions using MRI are related to validated…
Aim of total study:Diagnosing all components of RS in an objective mannerAim of present substudy:Increasing the reliability and decreasing the burden of the method with which glossoptosis can be determined in newborns with RS
We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.
The specific objectives are:1. What is the difference of in vitro CFTR function in CF patients with either mild (compound heterozygote A455E) mutations or severe (homozygote F508del) mutations with mild or severe clinical disease? 2. What is the…
Investigate the prevalence of rhinosinusitis and/or nasal polyps in adult patients with Cystic Fibrosis. Also several aspects of sinonasal disease are investigated; quality of life, correlation between phenotype and genotype, microbiology, anatomy…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…
Objectives: The aim of this study is to:I Identify pathogenic mutations in novel genes, causing PCDII Develop a diagnostic PCD test, based on MPSIII Validate MPS technique for PCD.
Investigation of the prevalence of sinonasal disease on CT-sinus in children with Cystic Fibrosis at different ages. This study will focus especially on the onset of sinonasal pathology in Cystic Fibrosis in relation to the development of the…
Objective of the study:The results of this study will lead to an improved insight in the lifecycle of these cells in health and diseases, and our results will be of importance for more insight in chronic inflammatory diseases particularly CF. For…
To assess whether TW and PW show differences in number, phenotype or function of regulatory T-cells in peripheral blood samples. Details on study determinants will be based on the outcome of the pilotstudy (Regulatory T cells in asthma; PREDART0807…
The study investigates the role of the RV efficiency in the deterioration of RV function to failure in PH (measured with stroke volume index as the parameter of RV function); efficiency will be related to MVO2, alterations in substrate metabolism…
To evaluate the predictive value of microcirculatory perfusion for the incidence of Extracorporeal Membrane Oxygenation (ECMO) dependency and consequently survival. To evaluate the effects of vasopressor drugs and iNO on microcirculatory perfusion.
We hypothesize that expiratory VOC-analysis by electronic nose is capable of: a.) discriminating CF-/PCD-patients with and without pulmonary infections and b.) discriminating CF-/PCD-patients and healthy controls.
Investigate the CGMS results in comparison with an OGTT and one-day self monitoring of blood glucose. Thereby compare the glucose patterns of patients with an impaired glucose tolerance to patient with a normal glucose tolerance and CFRD.
- To analyze retinoid levels in plasma and amniotic fluid from infants and mothers to establish the potential link between retinoids and CDH. - To establish a registry of blood and tissue samples that will be valuable for future studies of the…
1. Does exercise training improve muscle function and exercise tolerance in patients with IPAH?2. Does exercise training in IPAH result in morphological and biochemical changes of the quadriceps muscle?3. Does exercise training in IPAH result in…
The main objective of our Center for Translational Pediatric Pulmonology (CTPP) is to establish models of bronchial epithelial function in children, by (1) epithelial organoid cultures derived from bronchial epithelial cells; (2) bronchial brushings…