185 results
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
To determine whether the attenuated salivary cortisol response in children with asthma can be explained by the maintenance use of inhaled cortiocosteroids, the chronic inflammatory disease, or the attenuated exercise capacity.
In view of this lack of evidence and strong practice variation we propose a randomized clinical trial in overweight and obese subfertile women, in which we compare the costs and effects of a six months structured lifestyle program, aimed at weight…
To demonstrate differences in intracutaneous sodium storage between a control population, patients admitted after elective cardiothoracic surgery and septic patients.
1. To explore the validity and usefulness of Bone Microindentation Technique (BMT) in the assessment of bone quality in patients with osteoporosis and a spectre of bone diseases characterised with (localised) increased bone turnover. 2. To study the…
To determine the sensitivity and specificity of salivary metanephrines and in patients with PCC/sPGL.
The aim of this study is to investigate if the NETest is useful in the follow up program after curative resection in patients with pNET. Therefore the diagnostic accuracy of the NETest in resected patients with pNET will be analysed. The study is…
To compare Bone Material Strength of the tibia at the side of a fracture or arhtrodesis with that of the opposite tibia in patients who had been immobilized for at least 6 weeks after a recently sustained fracture of the ankle of calcaneus or after…
The aim of this study is to determine novel (bio)markers that show a stronger correlation with signs of over- and under-treatment than the conventional adrenal steroid profile in children with CAH.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
Objectives: Part 1) To assess the prevalence of PA in general practice (part 1 of this study);Part 2) To describe differences of cardiorenovascular damage in newly diagnosed hypertensive patients with versus without PA (part 2 of this study);Part 3…
To find new genes causing congenital MPHD associated with the characteristic MRI abnormalities of ectopic posterior pituitary gland and absent/thin pituitary stalk.
Imaging disease activity in patients with Graves' orbitopathy using [18F]-FDG-PET/CT - a pilot study
To determine whether 18FGD-PET/CT imaging is able to show difference in [18F]-FDG uptake in orbital tissue between patients with active and inactive GO.
The study aims to determine the value of combined 124I PET and FDG PET to avoid futile treatment with 131I. Secundary aims are to validate functional imaging with histopathological correlation, and to optimize and standardize the new 124I technique…
To study the extent of impaired urinary concentrating ability in hypothyroidism as well as the pathophysiological mechanisms involved before and after adequate treatment.
To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
1. Are there differences between patients and controls in circadian movement rhythmicity and sleep duration?2. Are these objective measures associated with subjective sleep complaints?3. Are these objective measures associated with decreased quality…
To find out if the mean thyroid volumes of healthy 10-12 and 17-18 years old Dutch children and adolescents are the same or larger than in the late nineteen nineties, and if the dietary iodine intake of these children and adolescents has decreased…
ObjectiveThe main goal of this investigation is to evaluate the thyroid hormone response in patients with TMNG and control subjects in response to various pharmacological and physiological stimuli, administered according to the dynamic exposure test…