26 results
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
To determine whether treatment with RAD001 10 mg/d plus Sandostatin LAR® prolongs the progression free survival (PFS) compared to treatment with Sandostatin LAR® alone in patients with advanced carcinoid tumor.
To determine if PHA-739358 has an antitumor activity against breast, ovaria, pancreatic, colerectal, small and non small cell squamous lung cancer.
To study whether there is an individual setpoint for the hypothalamus-pituitary-gonad axis in men
This observational cohort study is designed to evaluate the prevalence of acquired von Willebrand*s syndrome in patients with a new diagnosis of overt hypothyroidism.
To study in a large randomised double-blind trial, if the administration of levothyroxine at bedtime significantly changes TSH and thyroid hormone levels compared to morning administration. Furthermore we want to evaluate the change of quality of…
The objective of the study is to improve medical treatment of Cushing's disease by combining partially independent medical therapies which act through differential mechanisms. Given the high affinity of SOM230 to sst5 and considering the facts…
Aim of the study is to study the influence of GH receptor polymorfisms on the effects of growth hormone substitution in aduts with GH deficiency.
Whether cognitive functions in SGA children are impaired due to inappropriate developmental outgrowth in children born with a low birth weight is unknown. This is also the case for the fact whether GH treatment from the age of 4 years is still…
To investigate cortisol and ACTH rhythm (frequency, amplitude and regularity of cortisol and ACTH secretory pulses) in patients with SCS and bilateral adrenal involvement.
To determine whether treatment with RAD001 10 mg/d plus best supportive care prolongs the progression free survival (PFS) compared to treatment with Placebo plus best supportive care in patients with advanced pancreatic neuroendocrine tumor.
Primary objective:- To define the overall effect of oral Levothyroxine on coagulation parameters.Secondary objectives:- To define the specific effect of Levothyroxine on each tested coagulation parameters.- To define the specific effect of…
Comparing the reliability of a dietary-protein test with conventional Growth Hormone Stimulation Tests.
To identify risk factors that might contribute to the development of post-traumatic HHD in children in order to reduce the lag-time between onset and diagnosis for future patients. To investigate the level of functioning and the quality of life of…
The objective of the study is to provide access to sunitinib treatment for patients who have completed a prior sunitinib study and are judged by the investigator to have the potential to benefit from sunitinib treatment. During this study the…
The overall aim of this study is to examine, in adult female CCS in the Netherlands, the effects of treatment in general, and the effects of different types of treatment, doses of drugs, radiation sites and doses, and age at time of treatment, on: 1…
To study the variability of the lateralisation of the aldosterone/cortisol ratio*s when 3 instead of 1 sample is obtained and to study whether instantaneous measurement of cortisol during the procedure will prove to be advantageous.
More knowledge about the clinical aspects of the FMR2 gene mutation can complete the couseling. Carriers with the desire to start a family can take the chance on POF in consideration. The clinical symptoms of FXTAS can be differentiated from other…
(1) To establish the pharmacokinetic profile of clonidine following oral administration in children with suspected GH deficiency. (2) To relate the pharmacokinetics of clonidine to the observed expected (GH-response, cortisol response, depth and…