23 results
In view of this lack of evidence and strong practice variation we propose a randomized clinical trial in overweight and obese subfertile women, in which we compare the costs and effects of a six months structured lifestyle program, aimed at weight…
The purpose of this study is to find out if patients with locally advanced/metastatic Radioactive Iodine-refractory (RAI) thyroid cancer (papillary, follicular or Hurthle cell carcinoma), will benefit from sorafenib treatment compared to patients…
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
To determine that rhTSH pretretament during euthyroidism ( already available in an number of centra in the Netherlands) in a adequately powered study is as good as the classical way of inducing hypothyrodism by withholding suppletion which induces…
Main objectiveTo describe the experienced pain sensations of temperature and to describe the different temperature sensitivity thresholds using Quantitative Sensory Test (QST) in the different patient groups.secondairy objectiveAs a measure of the…
The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.
To compare the long term efficacy of pasireotide LAR vs. octreotide LAR at month 6 in controlling diarrhea and/or flushing in patients with metastatic carcinoid tumors whose disease-related symptoms are inadequately controlled by the maximum…
The primary objective is to evaluate health related QoL under an oral sequential treatment with natural steroid hormones: Duogestan®. The secondary objective is to evaluate the bleeding patterns over a one-year period.
The objective of the study is to determine whether it is necessary to take the blood pressure lowering medication (β-blocker, ACE-inhibitors or diuretics) of a patient into account prior to blood sampling for pheochromocytoma diagnostics. Therefore…
To evaluate health related QoL under an oral cyclic treatment with physiological steroid hormones: Duogestan®.
Do high plasma free fatty acids lower central serotonergic responsivity?
The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.
Primary objective: To explore whether prolonged moderate alcohol consumption affects in vivo cytokine response after a low dose of LPS in young, normal-weight men.Secondary objectives: To explore whether prolonged moderate alcohol consumption-…
To document cardiac function before and after treatment of CS.
To identify patients with TRalpha-1 mutations among adolescents with delayed puberty.
a. analysis of the usefulness of new molecular biological techniques in the diagnostic process of short stature, especially the detection of small chromosomal anomalies.b. identification of genetic factors causing short stature or influencing the…
Primary objective: To evaluate whether patients with a prolactinoma have signs of altered vascular function and/or morphology in the retina or sublingual tissues in comparison to healthy controls. Secondary Objectives: 1. To evaluate whether there…
- Objective (Study) 1.To evaluate the clinical performance of MET PET during rhTSH stimulation and to compare the results of this MET PET with the clinical rhTSH stimulated FDG PET in patients with negative post-treatment 131I-whole body scan (WBS)…
1. Study of the incidence of TART in male CAH children in a multicentre setting 2. Detection of predisposing factors for tumour growth. 3. Evaluating of gonadal function in male CAH children with TART
To find out whether T4 treatment of Down syndrome newborns until the age of 2 years compared with placebo treatment results in better cognitive or motor development at the age of 10 years and 6-8 months, and whether it is safe with regard to nerve…