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Use of Copeptin Measurement after Arginine Infusion for the Diagnosis of Diabetes Insipidus
- the CARGOx Study

The primary objective of this prospective international multicenter diagnostic study is the comparison of the diagnostic accuracy between copeptin measurement after arginine-stimulation (CAS) and the current best diagnostic test copeptin measurement…

Effect of donor Intestinal Microbiota Infusion on Thyroid function in patients with autoimmune HypOThyreoidism

To investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered every 8 weeks during 6 months through a small intestinal tube, has beneficial effects on residual thyroid function at baseline,…

An open-label, single-dose study to evaluate the excretion and metabolism of oral [14C]­-ONO-5788, and absolute bioavailability of oral ONO-5788 in healthy adult male subjects

The purpose of this study is to investigate how quickly and to what extent ONO-5788 is absorbed and how ONO5788 is eliminated from the body. . ONO-5788 will be labelled with 14-Carbon (14C) and is thus radioactive. In this way ONO-5788 can be traced…

Effect of sodium oxybate on brown adipose tissue activity in narcolepsy

Primary objective:1. To assess the effect of SXB treatment on cold-induced BAT volume and activity in narcolepsy type 1 patients.Secondary objectives:1. To assess the effect of SXB treatment on thermoneutral BAT volume and fat fraction, lipoprotein…

Optimizing timing of glucocorticoid treatment in children with congenital adrenal hyperplasia

To study the effects of 2 standard treatment timing strategies for glucocorticoid dosage on androgen concentration in CAH children: a. highest dosage in the morning, b. highest dosage in the evening.

MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women with Polycystic Ovary Syndrome: a multicentre double-blind randomised controlled trial

The primary objective of this study is to assess the effectiveness of myo-inositol supplementation to prevent pregnancy complications in women with PCOS. Secondary objectives are to evaluate the impact of supplementation on maternal (mental) and…

The uptake of radioactive iodine before and after a low iodine diet in patients with differentiated thyroid carcinoma

Primary objective: 1. To compare the difference in thyroid uptake of a low tracer dose radioactive iodine (10 MBq 123I or 37 MBq 123I) (1a), in DTC patients after thyroidectomy, before and after a LID of 7 days (1b).Primary objective described in…

Effects of discontinuation of levothyroxine treatment in older adults: a self-controlled study.

Primary aim1) To investigate what proportion of levothyroxine users aged 60 years and older can withdraw from levothyroxine treatment successfully, defined as having normal fT4 levels and TSH levels <10 mU/L at 52 weeks after start of the…

An open-label, multi-center, roll-over study to assess long term safety in patients with endogenous Cushing*s syndrome who have completed a prior Novartis-sponsored osilodrostat (LCI699) study and are judged by the investigator to benefit from continued treatment with osilodrostat

To evaluatie the long term safety of treatment with osilodrostat for patients with Cushing Syndrome. In addition to evaluating the proportion of patients with clinical benefit (as assessed by the investigator) and determening frequency, severity and…

Identification of the posterior lobe of the human pituitary gland during surgery using its electrophysiological, neural signature

To record and analyse the electrophysiological properties and differences of the human pituitary gland, i.e. the anterior lobe, posterior lobe and adenoma.

Improving Treatment Options for Somatostatin Type 2 Receptor Negative Neuroendocrine Tumor Patients

The aim of this prospective proof-of-concept study is to increase the expression of the SSTR2 in NET patients with negative or low expression to levels amenable for somatostatin analogue treatment through the use of epigenetic drugs.

The stress hormone COrtisol and the development of MEtabolic Syndrome and Cardiovascular DIseases
Unravelling the cause(s) of hypercortisolism in obesity:
Investigating the influence of the liver, gut and immune system

Primary Objective: - To investigate the differences between hypercortisolistic patients with obesity and normocortisolistic patients with obesity, with respect to hepatic steatosis, immunological factors, and the gut microbioma in order to obtain…

Targeted correction of plasma sodium levels in hospitalized patients with hyponatremia:
a randomized, controlled, parallel-group trial with blinded outcome assessment

The aim of this trial is therefore to determine the effects on mortality and rehospitalization rate of a targeted correction of plasma sodium concentration in addition to current standard care in hospitalized hyponatremic patients.

PRolaCT - three Multicenter Prolactinoma Randomized Clinical Trials

This study aims to investigate if endoscopic trans-sphenoidal prolactinoma resection as a first line treatment (PRolaCT-1), or as an equally valid second line treatment after a short (2-12 months) or long (>12 months) period of pretreatment…

Semen characteristics and testosterone levels in the general population

1. Evaluation of the variation of semen characteristics in the general population2. Evaluation of the variance of testosterone levels in the general population

Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in subjects with obesity before and after lifestyle intervention.

The objective of the study is to determine hypothalamic function in response to oral glucose ingestion in subjects with obesity before and after the start of a combined lifestyle intervention (CLI).

The THYRO-Dynamics study: Is the dynamics of thyroid hormones during cancer treatment in children adaptive or disruptive? - a prospective evaluation

This prospective evaluation of the dynamics of thyroid hormones during cancer treatment in children is designed to determine the prevalence of thyroid hormone deficits at diagnosis, during and directly after treatment and to study changes in thyroid…

Prospective randomized trial of an adjuvant therapy of completely resected Merkel Cell Carcinoma (MCC) with immune checkpoint blocking antibodies (Nivolumab, Opdivo®; Ipilimumab, Yervoy®) versus observation

Primary objective:To estimate the efficacy of adjuvant nivolumab monotherapy in completely resected MCC patients; i.e. the primary endpoint is Disease-free survival (DFS) in arm A at 12 months, defined as the number of patients alive and free of…

Quality of life and burden of disease in patients with hypoparathyroidism after thyroid surgery in the Southwestern region of the Netherlands.

The objective is to assess the impact of hypoparathyroidism on quality of life and the burden of disease.

Randomized, controlled growth hormone study in children and adolescents with a Prader-Willi-like phenotype, followed by a two year open-label growth hormone study - effects on body composition, growth, psychosocial development and quality of life

To investigate the effects of GH treatment on body composition, psychosocial development, psychomotor development, growth, glucose metabolism, serum lipids, cognition, behaviour, bone mineral density, quality of life and safety parameters in…