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Pilot-study: Dexamethasone and function of the HPA axis in children after treatment for Acute Lymphoblastic Leukemia; Relation to sleep

The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.

Brown adipose tissue activation on PET-CT in patients diagnosed with pheochromocytomas or Cushings syndrome.

Study the mechanisms of BAT activity and the effects of BAT acitivity on energy homeostasis.

Cardiovascular risk profile in pediatric CAH patients: a cross-sectional study

We hypothesize that cardiovascular risk factors may already be present during childhood in CAH patients. Therefore, we will perform a cross-sectional study in CAH patients aged 1-16 years evaluating blood pressure, lipid profile, insulin sensitivity…

Consequences of suboptimal glucocorticoid replacement therapy in Addison*s disease; The metabolic syndrome and quality of life.

Assess the prevalence of the metabolic syndrome and quality of life in patients with Addison*s disease treated with low dose GRT. Study the relation between GRT, QoL and glucocorticoid receptor polymorphisms

'Post-sarcoidosis' fatigue: a psychoneuroimmunologic approach

Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…

prevalence and etiological factors of testicular adrenal rest tumours in children and adolescents with congenital adrenal hyperplasia (CAH) - a multicentre study

1. Study of the incidence of TART in male CAH children in a multicentre setting 2. Detection of predisposing factors for tumour growth. 3. Evaluating of gonadal function in male CAH children with TART

The stress hormone COrtisol and the development of MEtabolic Syndrome and Cardiovascular DIseases
Unravelling the cause(s) of hypercortisolism in obesity:
Investigating the influence of the liver, gut and immune system

Primary Objective: - To investigate the differences between hypercortisolistic patients with obesity and normocortisolistic patients with obesity, with respect to hepatic steatosis, immunological factors, and the gut microbioma in order to obtain…