110 results
The present study will investigate the benefits of Genotropin® in patients suffering from severe GH deficiency after TBI and will focus on the potential effects on cognitive functionThe primary objective of this study is to establish the effects of…
The aim of this study is to classify hyothalamic dysfunction in patients treated for pituitary tumors. The hypothalamic functions will be investigated in different studygroups, these groups each have a different risk on hypothalamic dysfunction.
To study the prevalence of hypopituitarism and osteoporosis in patients 5 tot 10 years after severe traumatic brain injury
To examine the effects of odors and / or visual stimuli of food in subjects after 56h of starvation on:-Endocrine parameters-Metabolic parameters-Anthropometric parameters-Autonomic nervous system parameters-Hypothalamic function
To assess the efficacy of the co-administration of lanreotide Autogel 120 mg(administered via deep sub-cutaneous injections every 28 days) and pegvisomant(administered at 40 to 120 mg per week via sub-cutaneous injection given once ortwice a week)…
To collect data regarding the prevalence of:I) - osteoporosis in SCI patients and the relation to characteristics of SCI. - fractures in SCI patients and the relation to characteristics of SCI. - active treatment of osteoporosis in SCI patients.II…
Protocol 1: To determine whether pituitary dysfunction is present at intermediate duration of follow-up after traumatic brain injuryProtocol 2: To determine whether injury to brain tissue that explains traumatic brain injury-induced pituitary…
The purpose of this study, is to evaluate the efficacy and safety of pasireotide alone or in combination with cabergoline in patients with Cushing*s disease as measured by the proportion of patients achieving normal UFC at the end of the study…
Primary Objective- Compare the safety and efficacy of subcutaneous somavaratan and daily rhGH during 12 months of treatment.Secondary Objective-Evaluate and compare changes in pharmacodynamic responses (IGF-I, IGF binding protein-3 (IGFBP-3), growth…
This is a protocol aimed at standardizing clinical care and the diagnostic approach in a carrier of a pathogenic IGSF1 mutation referred for hormonal analysis to the outpatient clinic.
Research question:1. Do patients exhibit disturbances of sleep duration or circadian locomotor rhythmicity before surgery? 2. Do these variables change after surgery?
We aim to investigate whether copeptin can be used as an early postoperative marker for development of DI. We will measure copeptin levels in patients just prior to and following transsphenoidal surgery to be able to investigate whether copeptin…
Objectives:Primary Objective: • To assess the safety and tolerability of single and multiple ascending doses of BIM23B065 when given as a subcutaneous (s.c.) bolus injection in young healthy male subjects.Secondary objectives:• To determine the…
We aim to further study the characteristics of joint disease in acromegaly and its progression, in order to improve care for this patient group and to get insight into the pathogenesis of osteophytes and cartilage hypertrophy in acromegaly and in…
• To assess the prevalence of short stature, in combination with an aberrant IGF-1 in combination with IGF-BP3 in the entire cohort of childhood cancer survivors and the therapy related risk factors.• To assess the distribution of IGF-1 and IGF-BP3…
The primary objective of this prospective international multicenter diagnostic study is the comparison of the diagnostic accuracy between copeptin measurement after arginine-stimulation (CAS) and the current best diagnostic test copeptin measurement…
The primary objective of this study is to determine the feasibility of intraoperative fluorescence imaging detection of PitNET tissue during TSS using the VEGF-targeting optical agent bevacizumab-800CW in tumors with a Knosp grade of 3 or 4.…
To evaluate the effects of GH, after final height is reached, on weight, body composition, psychosocial functioning, carbohydrate metabolism and serum lipids. To find an optimal dose growth hormone for adults with PWS. We aimed to stabilize the body…
The purpose of this study is to investigate how quickly and to what extent ONO-5788 is absorbed and how ONO5788 is eliminated from the body. . ONO-5788 will be labelled with 14-Carbon (14C) and is thus radioactive. In this way ONO-5788 can be traced…
Primary objective:1. To assess the effect of SXB treatment on cold-induced BAT volume and activity in narcolepsy type 1 patients.Secondary objectives:1. To assess the effect of SXB treatment on thermoneutral BAT volume and fat fraction, lipoprotein…