17 results
The aim of this study is to investigate if the NETest is useful in the follow up program after curative resection in patients with pNET. Therefore the diagnostic accuracy of the NETest in resected patients with pNET will be analysed. The study is…
To evaluate the efficacy of pasireotide LAR and everolimus alone or in combination in progressive patients with a well differentiated neuroendocrine tumor of the lung or thymus.
The purpose of the study is to determine the sensitivity of dopamine platelets levels in patients with clinically suspected or diagnosed HNPGL, abdominal PGL, and pheochromocytoma. Primary Objective: The sensitivity of dopamine levels in platelets…
Evaluating the efficacy and safety of sunitinib in patients with progressive, advanced/metastatic well-differentiated, unresectable pancreatic neuroendocrine tumors.
To increase insight in the glucose metabolism in surgically treated PPGL patients by using dynamic FDG-PET/CT for analysis of tumor metabolic activity, blood fraction and full pharmacokinetic parameters. Furthermore, to correlate these finding with…
The objective of the study is to protract the sleep related complaints of patients with a carotid body tumor, especially with patients with a carotid body tumor. Patients will be divided in groups based on having a single sided or double sided GCT.…
The objective of the study is to provide access to sunitinib treatment for patients who have completed a prior sunitinib study and are judged by the investigator to have the potential to benefit from sunitinib treatment. During this study the…
We intend to employ an ex vivo model of human implantation to study the factors involved in successful implantation. By linking parameters of successful implantation with embryo quality markers, we aim to improve embryo selection and IVF outcomes.…
The aim of this prospective proof-of-concept study is to increase the expression of the SSTR2 in NET patients with negative or low expression to levels amenable for somatostatin analogue treatment through the use of epigenetic drugs.
Primary objectives pancreatic cancer:• In this clinical pilot study, we will assess the effect size to perform a power calculation for a subsequent clinical trial. Therefore we want to evaluate the ability of metabolic 7T MRI imaging to determine…
The aim of the study is to investigate whether SI-NET's can be visualized with Methylene Blue (MB) and near-infrared (NIR) fluorescence imaging.
This study has been transitioned to CTIS with ID 2024-513007-14-00 check the CTIS register for the current data. The current trial aims to asses the safety of this combination in a phase I trial with olaparib dose escalation during two cycles of…
This study has been transitioned to CTIS with ID 2023-504853-11-00 check the CTIS register for the current data. To evaluate the ORR of belzutifan per RECIST 1.1 by blinded independent central review (BICR).
This is a pilot study to validate the possibility of determining the effect of PRRT with 177Lu-DOTATATE on transcriptional regulation and DNA damage induction in PBMCs and how this is related to the radiation dose.We will also want to explore if we…
Primary objective:To estimate the efficacy of adjuvant nivolumab monotherapy in completely resected MCC patients; i.e. the primary endpoint is Disease-free survival (DFS) in arm A at 12 months, defined as the number of patients alive and free of…
To determine the objective response rate (ORR) (complete response and partialresponse) of RAD001 10 mg po qd monotherapy in patients with advanced(unresectable or metastatic) pancreatic NET after the failure of cytotoxicchemotherapy.
The aim of the study is to investigate whether SI-NETs can be visualized with indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging (FLI).