70 results
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
Firstly, to study the reduction in sick-leave time achieved by the treatment protocol. Secondly to study the quality of life in the patients treated in the fast-track protocol, to study the reduction in societal costs and to stdy the efficacy of a…
1) To study the late effects of 131-I treatment and TSH suppressive therapy as well as quality of life in patients with childhood-onset DTC. 2) To determine the presence of RET/PTC 1 and 3 translocations and BRAF mutations, and to investigate their…
To assess the physiological effects of metformin and hypocaloric dieting on thyroid iodide uptake and thyroid function in healthy volunteers.
1. Normalization of the abnormal serum TH parameters and thereby improving the clinical condition of the AHDS patients2. Observation of changes in cognitive and motor function.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
Long-term evaluation of thyroid disorders ( TSH elevation and the occurrence of thyroid nodi/carcinoma) in survivors of childhood NBL who received KI, methimazole and thyroxine as thyroid protection during 131I-MIBG exposure. Investigation of the…
Imaging disease activity in patients with Graves' orbitopathy using [18F]-FDG-PET/CT - a pilot study
To determine whether 18FGD-PET/CT imaging is able to show difference in [18F]-FDG uptake in orbital tissue between patients with active and inactive GO.
The study aims to determine the value of combined 124I PET and FDG PET to avoid futile treatment with 131I. Secundary aims are to validate functional imaging with histopathological correlation, and to optimize and standardize the new 124I technique…
To study the extent of impaired urinary concentrating ability in hypothyroidism as well as the pathophysiological mechanisms involved before and after adequate treatment.
To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
The family with the TRα2 premature stop enables us to investigate the biological role of the orphan wild-type TRα2 and the consequences of its dysfunction. The primary objectives of this proposal are (i) to search for a biological function of TRα2…
To find out if the mean thyroid volumes of healthy 10-12 and 17-18 years old Dutch children and adolescents are the same or larger than in the late nineteen nineties, and if the dietary iodine intake of these children and adolescents has decreased…
ObjectiveThe main goal of this investigation is to evaluate the thyroid hormone response in patients with TMNG and control subjects in response to various pharmacological and physiological stimuli, administered according to the dynamic exposure test…
This study aims to detect differences in sick leave time, associated costs and quality of life between differentiated thyroid cancer patients treated in either a fast-track protocol or a traditional longer time interval between total thyroidectomy…
Primary Objectives 1. To assess whether radioiodine therapy results in hyposalivation, altered saliva composition and xerostomia in DTC patients.2. To assess whether the extent of radioiodine uptake on the pre- and post-therapy WBS and SPECT/CT is…
To assess the changes in cardiac function and the microcirculatory function in different thyroid states. We aim to identify how thyroid state affects changes in micro and macro hemodynamics.
To determine that rhTSH pretretament during euthyroidism ( already available in an number of centra in the Netherlands) in a adequately powered study is as good as the classical way of inducing hypothyrodism by withholding suppletion which induces…
Immunodetection of Thyrothrophin (TSH) receptor in myometrium tissue.Furtermore the aim is to test myometrium tissue in vitro for it's relaxation and contractility and it's conductance of electropotentials.