33 results
Main objective: To test the efficacy of thyroxine replacement for subclinical hypothyroidism (SCH) in older adults. Primary Objective: To determine multi-modal effects (quality of life; cognitive; musculoskeletal and cardiovascular) of levo-…
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
First objective: To assess improvement in live birth rate after levothyroxine supplementation. Secondary objective: 1) to test the hypothesis that levothyroxine lowers the risk for miscarriage and preterm birth 2) to test the hypothesis that…
1. Does Levothyroxine treatment for subclinical hypothyroidism give multi-modal benefits for the oldest old people with subclinical hypothyroidism?2. Are benefits seen across a wide range of outcomes, including prevention of cardiovascular disease,…
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
Long-term evaluation of thyroid disorders ( TSH elevation and the occurrence of thyroid nodi/carcinoma) in survivors of childhood NBL who received KI, methimazole and thyroxine as thyroid protection during 131I-MIBG exposure. Investigation of the…
To study the extent of impaired urinary concentrating ability in hypothyroidism as well as the pathophysiological mechanisms involved before and after adequate treatment.
To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
To assess the changes in cardiac function and the microcirculatory function in different thyroid states. We aim to identify how thyroid state affects changes in micro and macro hemodynamics.
Immunodetection of Thyrothrophin (TSH) receptor in myometrium tissue.Furtermore the aim is to test myometrium tissue in vitro for it's relaxation and contractility and it's conductance of electropotentials.
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
The aim of this study is to investigate how often thymic hyperplasia is present in Graves' disease. Moreover we will investigate if thymic hyperplasia in Graves' disease is caused by stimulation of T cell development in the thymus.
To study the effect of thyroid hormone and thyroid-stimulating hormone on brown adipose tissue activity.
To investigate the effect of resistance to thyroid hormone (RTH) due to a TRβ mutation on coagulation and fibrinolysis
To identify patients with TRalpha-1 mutations among adolescents with delayed puberty.
This observational cohort study is designed to evaluate the prevalence of acquired von Willebrand*s syndrome in patients with a new diagnosis of overt hypothyroidism.
Primary objective:- To define the overall effect of oral Levothyroxine on coagulation parameters.Secondary objectives:- To define the specific effect of Levothyroxine on each tested coagulation parameters.- To define the specific effect of…
To gain insight in the relation between maternal thyroid function and maternal emotional complaints during pregnancy and the development of the child in relation to the self-regulation capacities of the child.
Hypothesis:In auto-immune hyperthyroidism there is an increase of (eosinophil)airwayinflammation compared to healthy test subjects.Objective:testing our hypothesis by answering the following questions:1. What is the difference in NO in exhaled air…