29 results
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
To assess the physiological effects of metformin and hypocaloric dieting on thyroid iodide uptake and thyroid function in healthy volunteers.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
To study the extent of impaired urinary concentrating ability in hypothyroidism as well as the pathophysiological mechanisms involved before and after adequate treatment.
To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.
The family with the TRα2 premature stop enables us to investigate the biological role of the orphan wild-type TRα2 and the consequences of its dysfunction. The primary objectives of this proposal are (i) to search for a biological function of TRα2…
This study aims to detect differences in sick leave time, associated costs and quality of life between differentiated thyroid cancer patients treated in either a fast-track protocol or a traditional longer time interval between total thyroidectomy…
To assess the changes in cardiac function and the microcirculatory function in different thyroid states. We aim to identify how thyroid state affects changes in micro and macro hemodynamics.
Immunodetection of Thyrothrophin (TSH) receptor in myometrium tissue.Furtermore the aim is to test myometrium tissue in vitro for it's relaxation and contractility and it's conductance of electropotentials.
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
The aim of this study is to investigate how often thymic hyperplasia is present in Graves' disease. Moreover we will investigate if thymic hyperplasia in Graves' disease is caused by stimulation of T cell development in the thymus.
To study the effect of thyroid hormone and thyroid-stimulating hormone on brown adipose tissue activity.
To investigate the effect of resistance to thyroid hormone (RTH) due to a TRβ mutation on coagulation and fibrinolysis
To identify patients with TRalpha-1 mutations among adolescents with delayed puberty.
This observational cohort study is designed to evaluate the prevalence of acquired von Willebrand*s syndrome in patients with a new diagnosis of overt hypothyroidism.
To find out whether T4 treatment of Down syndrome newborns until the age of 2 years compared with placebo treatment results in better cognitive or motor development at the age of 10 years and 6-8 months, and whether it is safe with regard to nerve…
Primary objective:- To define the overall effect of oral Levothyroxine on coagulation parameters.Secondary objectives:- To define the specific effect of Levothyroxine on each tested coagulation parameters.- To define the specific effect of…
To gain insight in the relation between maternal thyroid function and maternal emotional complaints during pregnancy and the development of the child in relation to the self-regulation capacities of the child.
Hypothesis:In auto-immune hyperthyroidism there is an increase of (eosinophil)airwayinflammation compared to healthy test subjects.Objective:testing our hypothesis by answering the following questions:1. What is the difference in NO in exhaled air…
We aim to investigate whether a relation between intestinal microbiota composition, mucosal integrity and translocation of bacteria into adipose tissue of the affected eye is related to the severity of Graves orbitopathy.