Search for a trial

Clinical Evaluation of the Edwards Lifesciences Monarc system for the treatment of Mitral Regurgitation

To demonstrate the safety, efficacy, and performance of the Edwards Lifesciences MONARCTM system for the treatment of functional mitral regurgitation

Study of Myocardial Recovery after Exercise Training in Heart Failure

The extent of beneficial effects of AIT, including reverse remodeling and improved left ventricular function, exercise capacity, quality of life and level of physical activity, needs to be established in a phase II type clinical multicenter study…

A Prospective, Multicenter, European Registry Investigating the Lutonix Paclitaxel-Coated Balloon for the Treatment of In-Stent Restenosis within Bare-Metal Stents

To assess angiographic and clinical outcomes after treatment of ISR of a prior BMS in the native coronary system with the Lutonix Catheter

The Effects of Epidermal Growth Factor Receptor (EGFR) Inhibition on Pulmonary Arterial Hypertension Associated with Systemic Sclerosis
A phase II controlled open-label safety and efficacy study.

The first objective is to evaluate the safety of cetuximab in patients with scleroderma associated PAH. The secondary objective is to assess efficacy.

Protect: Clinical evaluation of pacing during the onset of revascularization. Clinical feasibility study

The purpose of this study is to determine whether the application of ventricular pacing during PCI for AMI can protect the human heart from damage as a result of ischemia/reperfusion injury

NGAL Evaluation Along with B-type Natriuretic Peptide in Acutely Decompensated HF

The statistical analysis will evaluate the correlation of Baseline NGAL and BNP levels -alone and together - with the clinical outcomes of hart-failure (HF-related adverse clinical outcomesthrough Day 30 and Day 90. The cut-off and estimated…

Organ protection by noble gases * A clinical study to investigate Helium induced Pre- and Postconditioning in patients undergoing coronary artery bypass surgery.

The aim of this clinical study is to investigate whether the non-anaesthetic noble gas helium induces preconditioning (PreC) and postconditioning (PostC) in patients undergoing coronary artery bypass graft (CABG) surgery

A Phase 2, Placebo-Controlled, Randomized, Double-Blind, Parallel Arm, Dose Ranging Study to Evaluate Safety and Efficacy of Apixaban in Patients with a Recent Acute Coronary Syndrome

To evaluate the safety (bleeding) of 4 doses of apixaban as compared to placebo over a 26 week treatment period in selected subjects with recent (<=7 days) Acute Coronary Syndrome (ACS). To determine the optimal dose and regimen of apixaban…

Rheos Diastolic Heart Failure Trial

The purpose of this clinical investigation is to describe the safety and efficacy of the Rheos Baroreflex Activation Therapy System in subjects with diastolic heart failure.

Organ protection by noble gases * Helium induced Early and Late Preconditioning (HELP) in human endothelium

The aim of this clinical study is to investigate whether the non-anaesthetic noble gas helium induces EPC and LPC of human endothelium in vivo.

Acute cardiac resynchronization therapy for right ventricular disease

To attenuate the clinical severity of right ventricular disease by electrical pacing

The effect of rosiglitazone on ischemia-reperfusion-injury using annexin A5 scintigraphy.
A double blind placebo- controlled cross-over study in subjects with the metabolic syndrome

To estimate the effect of rosiglitazone compared to placebo on ischemia-reperfusion injury as assessed by annexin A5 scintigraphy in the human forearm in subjects with the metabolic syndrome.

A Randomized, Double-blind, Double-dummy, Active-controlled, Parallel-group, Multicenter Study to Compare the Safety of Rivaroxaban versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Subjects with Acute Coronary Syndrome

To estimate the bleeding risk with rivaroxaban, compared with ASA, in addition to a singleantiplatelet agent (clopidogrel or ticagrelor), in subjects with a recent ACS .

Prospective, multi-center, randomized First-In-Man trial to compare the safety and efficacy of BuMA Supreme eG (Electro Grafting) based biodegradable polymer Sirolimus-eluting stent against Resolute Zotarolimus-eluting durable polymer stent in patients with de novo coronary artery lesions.

To evaluate the safety and effectiveness of the SINOMED BuMA Supreme Sirolimus-Eluting Coronary Stent System with biodegradable polymer versus the Medtronic Resolute Zotarolimus-Eluting Coronary Stent System through angiographic and clinical…

Right vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system*

to improve RV function adult patients with RV dysfunction due to tetralogy of Fallot

Effect of ivabradine versus placebo on cardiac function, exercise capacity, and neuroendocrine activation in patients with Chronic Heart Failure with Preserved left ventricular Ejection Fraction;An 8-month, randomised double-blind, placebo controlled, international, multicentre study.

The primary objective of this study in patients with symptomatic chronic Heart Failure and Preserved left ventricular Ejection Fraction (HF-PEF) is to determine whether ivabradine compared to placebo could improve the diastolic function, the…

MERIT Study - Mistral Percutaneous Mitral Valve Repair FIM Study

The study is designed to clinically demonstrate device acute safety (Primary Endpoint) along with longer FU device safety and effectiveness evaluation (Secondary Endpoint).The main objectives of the study areU :1) Evaluate the Acute safety of the…

Safety, tolerability and sedative properties of single dose intranasal dexmedetomidine premedication in elderly subjects.

This study aims to evaluate the safety, tolerability and sedative proporties of a single dose of intransally administered dexmedetomidine in person odler than 65 years, differentiating between person using beta-blocking medication and those not…

A randomized, double blind, placebo-controlled, parallel, international multicenter study assessing the efficacy of S066913 in patients with paroxysmal atrial fibrillation.
Double-blind, International study AssessinG efficacy of S066913 in paRoxysmal Atrial Fibrillation -IKur inhibitor (DIAGRAF - IKUR)

The aim of this study is to evaluate the efficacy of three doses of S 066913 (5 mg, 25 mg and 100 mg o.d.) versus placebo administered for 4 weeks on atrial fibrillation and/or atrial tachycardia burden (AF/AT burden) in patients with paroxysmal…

A 2-stage study to evaluate single doses of MZ-004 at different dose levels in patients with chronic total occlusions. STAGE 1: Open label Training Stage. STAGE 2: Double-blind, randomized, Placebo-Controlled Stage. The TOSCA-5 Study (Total Occlusion Study in Coronary Arteries-5)

To obtain an estimate of the anterograde PCI success rate for patients with a confirmed target CTO in each treatment group and to explore safety and tolerability in these patients.