86 results
Objectives: 1. To what extent does the CVRM risk profile and co-morbid conditions differ between individuals with (UCC-SMART) and without (UHP-UCC) symptoms of heart failure, but with similar levels of echocardiographic structural- and functional…
We aim to investigate if aortic stiffness, measured by pulse wave velocity (PWV), is present in patients with DMD and whether treatment with ACEi reduces aortic stiffness.
Part I- To determine the impact of PE on incidence of macro-and micro-vascular dysfunction reflected by surrogate measures for coronary artery disease (CAD) and HFpEF, and potential deterioration over time.- To perform a genome wide association…
Objective: To assess if skeletal muscle metabolism is impaired in HFpEF patients with iron deficiency compared to HFpEF patients without iron deficiency?
To identify differences in peripheral microvascular function in HFpEF patients compared to controls without HFpEF, corrected for important confounders of microvascular function
Primary 1) Establish whether HTx induces a trained immunity phenotype of circulating mono-cytes in pediatric and adult HTx patients, and compared to healthy controls.2) Investigate whether trained immunity phenotypes in pediatric and adult HTx…
To optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy phenotypes and to create a better understanding of underlying pathophysiological processes.
To investigate the association of biomarker measurements (NT-proBNP, hsTroponin-T, CKMB, myoglobin, GDF-15, CRP, IL-6, IL-10, PCT, galectin-3, ST-2, albumin) during an SBT with extubation failure in mechanically ventilated ICU patients.
The main objective of the HELPFulUP study is to investigate deterioration of the diastolic function towards HFpEF in individuals with pre-clinical LVDD The secondary objective is to relate the progression towards HFpEF to clinical characteristics…
Primary objective of this study is to enhance insight in differences in elemental cardiovascular physiology between different levels of VA-ECMO support, by comparing pressure-volume loop derived parameters between 4.0-3.0-2.0-1.0-0.5 L/min…
We hypothesize that the development of a follow-up program of unaffected mutation carriers will lead to early identification of disease and in the development of strategies to prevent the development of disease and successful treatment.
- to evaluate the prevalence of (sub)clinical CVD, cardiovascular risk factors and metabolic abnormalities among BC survivors treated with and without anthracyclines in two groups at (a) 5-7 years and (b) 10-12 years after diagnosis;- to…
The main goal of this study is to explore the pattern of physiologic and pathophysiologic cardiac recovery after a preeclamptic pregnancy compared to a normotensive pregnancy, up till 18 months PP.To study the link between placental acute atherosis…
To evaluate the presence and extent of myocardial inflammation, fibrosis and myocardial perfusion in SSc patients with either PH-LHD or PAHPAH and/or PH-LHD, in comparison to patients with idiopathic pulmonary arterial hypertension (IPAH) by means…
To obtain sex-specific biomarkers, based on pathogenesis of microvascular disease, that improve the early diagnosis of diastolic dysfunction and HFPEF. These biomarkers come from innovative sources such as circulating endothelial cells,…
In this explorative-study, we aim to investigate the relation between cDPP3 release kinetics and clinical outcome parameters in OHCA patients after ICU admission. This could lead to the identification of a new predictive marker, a potential…
1- To estimate the prevalence of cardiac abnormalities, defined as systolic dysfunction, cardiovascular risk factors in CCS who have received anthracyclines, mitoxantrone and / or radiotherapy to the heart region compared with sibling controls and…
The primary objective of this study is to validate 31P-MRS as a non-invasive in vivo measure of mitochondrial function. Secondary objectives are to determine whether there is mitochondrial dysfunction in the heart of type 2 diabetic patients and to…
We aim to assess the association between (cardio-)vascular and hemodynamic factors in relation to cognitive function.
To assess the inflammatory secretome of EAT, its subsequent interaction with cardiomyocytes, and its potential implication in the development of LV diastolic dysfunction.