37 results
The primary objective is to correlate the properties of the right ventricular strain-area loop to the properties of the right ventricular pressure-volume curve.
The purpose of the study is to investigate how quickly and to what extent neladenoson bialanate is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). Neladenoson bialanate to be…
The purpose of the study is to examine how the Minicare I-20 fits into the ambulance workflow. Relevant process data of the ambulance workflow was collected (stage 1) looking specifically into chest pain patients. This second stage will focus on…
To perform a detailed non-invasive analysis of mechanical activation under different volume loading conditions and to describe the accompanying hemodynamic response.
During this pilot study, we intend to investigate the feasibility of a home-based patient-tailored telemedicine self-management intervention for patients with COPD and chronic heart failure over a 4-month period.
To evaluate the safety and tolerability of ascending multiple PO doses of AMG 986 in heart failure patients (Part C).* To characterize AMG 986 pharmacokinetics (PK) after IV infusion and oral administrationin heart failure patients.* To characterize…
The primary objective of this study is to develop an objective, clinical relevant classification model of disease severity for patients with HF based on an extensive, complete dataset of patients with HF.
Primary objectives:* To show non-inferiority in acute hemodynamic effect between the best LV septal pacing side and conventional BiV pacing in heart failure patients who are candidates for CRT. Conventional BiV pacing is defined by simultaneously…
Cardiac surgery patients are often exposed to blood products perioperatively (18). Due to their underlying cardiac condition and ventricular dysfunction these patients are at an increased risk for TACO.(19) In a *proof of principle* approach we will…
The main objective of this study is to test the effects of combined SGLT1 and SGLT2 inhibition with sotagliflozin on hemoconcentration and plasma volume in patients with heart failure.
The primary objectives of this study are:- To demonstrate that LCZ696 is superior to individualized medical therapy for comorbidities in reducing NT proBNP from baseline after 12 weeks of treatment in patients with HFpEF.- To demonstrate that LCZ696…
The primary objective is to determine to which extent the MET score as estimated by the MET-REPAIR questionnaire correlates to the physical capacity level as measured by the 6MWT.The secondary objective is to determine to which extent the following…
The primary objective of the present study is to determine the accuracy of the Fitbit Charge 2 for the assessment of energy expenditure in patients with chronic heart failure and coronary artery disease. The secondary endpoint is to determine the…
Our primary aim is to determine whether the changes of the strain-volume loop can be used to detect an acute change of the afterload (and thus heamodynamics) of the heart in healthy subjects.Our secondary aim is to determine whether age influences…
The purpose of this clinical study is to evaluate the safety and efficacy of the Attain Stability Quad MRI SureScan LV lead (Model 4798) in patients indicated for a de novo LV lead implant. This will be assessed through primary safety and primary…
The objective of this clinical investigation is to assess and characterize the clinical management of HeartMate 3 LVAD patients guided by hemodynamic parameters provided by the CardioMEMS HF System as a clinical hybrid construction to optimize…
Our pilot study is designed to obtain data on sensitivity of g-cfDNA with the ddPCR technique to diagnose tissue rejection in heart transplant recipients, as determined by the golden standard EMB.
Primary Objective:The primary objective is to evaluate the effects of various doses of BMS-986231 compared to placebo on clinically relevant hypotension (defined by SBP < 90 mm Hg or symptoms of hypotension)Secondary Objectives:* Assess the…
To explore efficacy and safety of terlipressin in pre-capillary PH patients with RV failure requiring hospitalization.
The objective is to compare, within current guidelines (GL) and instructions for use (IFU), an abbreviated versus a prolonged DAPT duration after bioresorbable polymer coated Ultimaster sirolimus-eluting stent implantation in patients presenting HBR…