386 results
Primary objective: to identify intra-individual changes of clinical and biochemical markers of AT characteristics before, and one year after bariatric surgery by:* Determining circulating AT derived biomarkers * Determining local AT biomarkers in…
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
The primary objective of the study is to outline the advantages of LP implantation in TAVI patients who require temporary, and possibly permanent pacing compared to the Standard of Care using TV-TP therapy. We will study whether placement of a LP…
Optimise post PVI management using ambulant continuous patient-driven eHealth monitoring after catheter ablation in the treatment of atrial fibrillation.Primary Objective:1) Determine the effect of eHealth on clinical management, outcomes and…
To determine the within and between variability of pharmacokinetic (PK) profiles in patients treated with DOACs in daily practice
To determine the lowest energy which successfully converts induced ventricular arrhythmias in S-ICD patients.
Primary objective: To compare at baseline the exact phenotypes of patients with young AF with versus without familial AF. Assessment of the phenotype includes clinical characteristics, presence of validated AF risk factors, (electro-)…
Primary Objective: to compare the atrial contractility by means of echocardiography between patients receiving flecainide and vernakalant i.v. after conversion to sinus rhythmSecondary Objective(s): 2a. To compare the conversion rate of AF between…
To investigate the real incidence of POAF a Reveal device is implanted. Afterwards a risk stratification of POAF is made.Using modern mapping equipment and techniques, it is now possible to investigate the substrate for development of atrial…
1) To improve our understanding of the underlying pro-arrhythmic substrate and electrophysiologic mechanisms of VA in NICM, and to develop individualized treatment for VA based on the identified substrate. 2) To improve risk stratification for VA…
The primary objective of this study is to validate that the reduced system dose setting with Xres4 translate into an overall procedure dose reduction. Procedure dose will be determined by the cumulative dose area product (DAP) value and the…
The primary purpose is to assess the defibrillation efficacy of Medtronic subcutaneous defibrillation system.
Answering the following questions:1. Main question: Is remifentanil a usefull medication for PSA in the emergency department?2. What is the recovery time of the patient when using fentanyl / propofol / remifentanil (time between last gift PSA…
To evaluate the safety and performance of the BackBeat Moderato system.
Primary objectives: To find out whether catheter ablation in the very early stages of AF ( i.e. no structural nor electrical remodeling) compared to AADs leads to 1) more effective rhythm control after a blanking period of three months during an…
The purpose of the study is to demonstrate that in patients of 65 years or older with symptomatic paroxysmal atrial fibrillation (AF) pulmonary vein isolation (PVI) using RF ablation therapy is superior to medical treatment with amiodarone to…
Primary objective:• To investigate whether Enhanced programming is safe for primary and secondary prevention patientsSecondary objectives:• Investigate the impact of Enhanced programming on adverse events (related to ICD shock with consequences and…
The purpose of this clinical study is to evaluate asymptomatic cerebral embolic (ACE) in subjects with symptomatic paroxysmal atrial fibrillation (AF) undergoing ablation with the Pulmonary Vein Ablation CAtheter GOLD (PVAC GOLD).(See also p. 13 of…
The main objective is to find markers for arrhythmia vulnerability in patients with end stage heart failure.
To investigate whether high resolution multi-site epicardial mapping of the atria in patients with structural heart disease undergoing cardiac surgery can identify patients at risk for developing early post-operative atrial fibrillation. The…