386 results
The aim of this study is to collect data to confirm clinical safety and performance of the Amvia pacemaker family to fulfil the regulatory requirements for products that are available on the market. The collected data may also be used to support…
To assess the prevalence of subclinical AF in obesity patients by using different contemporary AF-detection applications (primary objective). To investigate the potential role of GLS as a parameter to predict presence of AF in obesity patients (…
The objective of the ADVANTAGE AF Study is to establish the safety and effectiveness of the FARAPULSE Pulsed Field Ablation System (FARAPULSE PFA System) for treatment of drug resistant, symptomatic persistent atrial fibrillation (PersAF).
The primary objective of this trial is to quantify the incidence of AF in patients at high risk for but without previously known AF using a smartwatch wearable with a photoplethysmographic sensor and to determine if the incidence is higher compared…
This study is designed to investigate successful left common PV antrum isolation and to determine lesion characteristics after PFA in patients with AF.
Evaluate and quantify whether lesion formation can be visualized using MRI in subjects undergoing a catheter ablation for paroxysmal atrial fibrillation.
To identify arrhythmogenic electromechanical risk profiles in LQTS patients; in baseline conditions and during provocation; the recognition of risk profiles will improve risk stratification for sudden cardiac death.
To compare efficacy and cost-effectiveness of early AF ablation by PVI using cryoballoon therapy with standard (medicinal) therapy in patients with heart failure with reduced ejection fraction.
Primary objective: This is a Post Market Clinical Follow-up (PMCF) study designed to establish the continued safety and effectiveness profile of the Boston Scientific Cardiac Cryoablation System after receiving CE mark.Secondary objective: The study…
Evaluate the effect of the menstrual cycle on QTc among females with LQT1 or LQT2 and to put our previous findings in a broader perspective by including controls groups and older females.
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal, neurocognitive and cardiovascular health (dependent variables) of professional…
The primary objective is to evaluate whether the impact of a strategy aimed at switching INR-guided VKA management to a NOAC-based treatment strategy is superior in terms of the occurrence of major or clinically relevant non-major bleeding…
To test the acute effect of beta-blockers vs flecainide on the reduction of PVCs in a pediatric population. Secondary objectives are to perform a prospective evaluation of the effect of PVCs on LV function, to test the effect of reduction of PVCs by…
To measure DOAC levels just before surgery of all DOAC patients in the LUMC with elective surgery for which ceasing of DOAC treatment is required.
To investigate the incidence of new-onset AF in patients with CAD and a single chamber ICD.
To establish normal reference values for the foetal LVIRT and myocardial contraction duration using respectively echocardiographic Doppler tracings and cTDI at a foetal age around 20, 28 and 30 weeks* gestation. These reference values will be…
Primary Objectives are to• identify novel (likely) pathogenic genetic variants in familial or young AF patients.• investigate the relation between genetic profiles and electrical (AF) phenotypes.• develop a specific gene panel for AF• construct a…
The objective of this clinical trial is to demonstrate that ablation with the TactiFlex PFA System is safe and effective for the treatment of symptomatic, recurrent PAF.
Primary objective: To measure AF burden at population level.Secondary objective: Associate the AF burden with risk profiles in the general population.
Primary Objective:The study aims to assess freedom from AF ten years after the procedure without the use of antiarrhythmic drugs in patients who underwent thoracoscopic ablation in advanced AF with or without GP ablation. Secondary Objectives:1. To…