97 results
In patients with NSTEMI we aim to: 1) compare coronary vulnerable plaque detection between 18F-NaF-PET-CMR and invasive coronary angiography, 2) investigate the relation of coronary vulnerable plaques using 18F-NaF-PET with myocardial infarction…
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
To answer the following research questions: 1. Do intimal arterial calcification and medial arterial calcification in the lower extremity arteries increase the occurrence of cardiovascular disease in people with a high risk of cardiovascular disease…
Determining the role and influence of genetics, their polymorphisms and immunologic phenotype in arteriogenesis in patients with obstructive coronary artery disease (CAD).
To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.
The goal of this pilot study is to investigate whether circulating monocytes of patients with MCD are characterized by a trained phenotype, so we can ascertain whether trained innate immunity may contribute to microvascular wall inflammation in…
to identify novel molecular pathways resulting in premature atherosclerosis (PAS) in families where the traditional risk factors are not present / near absent.
In the current study, we want to determine and correlate the results of both perfusion capacity (with MR imaging) and sublingual glycocalyx dimensions in a) patients with proven obstructive coronary artery disease and b) patients with angina but…
The primary objectives of our study are:1. to compare the diagnostic performance of coronary CTA with coronary MRA to detect significant coronary stenoses (> 50% reduction in lumen diameter), in patients with a range of coronary calcium…
• To investigate the magnitude and time course of platelet reactivity and platelet activation in patients with a STEMI undergoing primary percutaneous coronary intervention (pPCI).• To investigate the magnitude and time course of thrombin generation…
In this study, we will assess the reproducibility of the observed dose-dependent inhibiting effect of CK on platelet aggregation.
1) identifying new predictors of ST, in particular of late and very late ST and drug eluting stent thrombosis2) to observe clinical outcome after an episode of a ST
To understand why statins are able to decrease the risk of developing venous thrombosis, by analyzing whether statins can influence pathways that inhibit coagulation.
To investigate the risk of deeath and incident (cardio)vascular disease in patients with a TIA or stroke aged 18-50 yearsTo investigate the riks of cognitive impairment and (vascular) dementia in patients with a TIA or stroke aged 18-50 yearsTo…
1) To investigate the differences in lipid content of the plaques after placement of a Stentys self-apposing stent. 2) To investigate whether there is a correlation between the decrease lpid-core content and the increase in cardiac biomarkers (…
The aim of this study is to identify risk factors for development of cardiovascular disease after TC treatment.
the aim of this study is to compare the impact of an early-CR within 48 hrs. after PPCI to a late complete revascularization >2 weeks after PPCI on LV remodelling in patients with STEMI and multi-vessel disease.
To obtain human fibroblasts from extreme dyslipidemia patients or patients with premature atherosclerosis to study cholesterol metabolism.
To investigate the innate pro-inflammatory response in young patients (<50 years of age), who suffer from a myocardial infarction. The pro-inflammatory response will be examined by the search for *trained immunity* especially in the monocytes…