36 results
The objective of this study is to measure the effect of a smart technology intervention on patients after AMI.
To gain qualitative insights into the value of the *ACS post-discharge self-management proposition* for patients, medical staff and care institution. Understand how this prototype is used in practice by patients and staff * Investigate how it…
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
The current research proposal therefore aims to examine the relation between a range of psychological risk factors and several mental stress-induced physiological responses in a large sample of PCI patients.
To test the hypothesis that 6 months DAPT after second generation DES implantation in STEMI is not inferior to 12 months DAPT in terms of clinical outcomes (composite endpoint of all-cause mortality, any MI, any revascularization, stroke and major…
To quantify the impact of the use of the HEART risk score on patient outcome (major adverse cardiac events(MACE) and quality of life) and on costs in patients with chest pain presenting at the emergency room.
The purpose of the study is to assess the diagnostic accuracy of a combined use of non-invasive coronary angiography with multi-slice computed tomography (MSCT) and stress cardiac magnetic resonance (CMR) imaging in patients with obstructive lesions…
To test the non-inferiority of 6- versus 12- month dual antiplatelet therapy in patients with lesions treated with at least one second generation DES.
This study evaluates if there is a difference in platelet function during and following the use of minimal ECC compared with conventional ECC in coronary artery bypass grafting (CABG) analysed with tromboelastography en multiple electrode aggrometry…
The purpose of the GLOBAL study is to perform whole-genome genotyping, next-generation deep resequencing, gene expression profiling, metabolomics, lipidomics and proteomics of atherosclerosis in patients phenotyped using advanced CT-based imaging…
Main objective is to test if the pharmacogenetic profile that is associated with a decreased response to ACE inhibitor therapy influences the bradykinin B1 receptor induced inflammatory response.
Please see pages 3-5 of the Protocol
Does CPB affect microcirculatory function by comparing on-pump (CON-CPB) and off-pump (OFF-PUMP) cardiothoracic surgery?Does pulsatile flow during cardiopulmonary bypass (PULSE-CPB) improve microcirculatory function as compared to continuous flow (…
The objective of this study is to determine the feasibility of a RCT that study the effectiveness on mortality and morbidity of cardiovascular preventive medication in people >=75 years without previous cardiovascular disease, without…
a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…
Our primary objectives are to evaluate - if endogenous EPO, EPC levels and EPC function are different in patients with stable and unstable CAD, compared to age and sex matched controls;- if a correlation exists between endogenous EPO and EPC levels…
The goal of the proposed study is to investigate a preexisting psycho-biochemical risk profile for major adverse cardiovascular events (MACE) and patient perceived symptoms in a group with angiographically confirmed, but non-acute, coronary artery…
Does dexamethason reduce the levels of plasma inflammatory proteins in patients undergoing coronary artery bypass graft (CABG) surgery who have a normal or disturbed ejection fraction such that proapoptotic pathways are inhibited?Does a…
The objective of the proposed study is to evaluate the efficacy on risk factor management and toevaluate cost-effectiveness of an internet-based risk factor management program for patients at highcardiovascular risk.The research questions are…
to compare the difference in weaning by ASV and PC/PS