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Randomized clinical trial for an extended cardiac rehabilitation program using telemonitoring

To assess whether an extension of the cardiac rehabilitation program with telemonitoring guidance results in better long term effects on physical and mental outcomes than a regular follow-up period after traditional cardiac rehabilitation.

Cardiovascular outcomes study to evaluate the potential of aleglitazar to reduce cardiovascular risk in patients with a recent acute coronary syndrome (ACS) event and type 2 diabetes mellitus (T2D)

To determine whether aleglitazar reduces cardiovasculair mortality and morbidity (defined as non-fatal myocardial infarction (MI) and non-fatal stroke) in patients with a recent ACS event and type 2 diabetes.

Cardiovascular system in Children with Cystic fibrosis

We hypothesised that cardiovascular changes already exist in children with cystic fibrosis compared with healthy control children. Therefore, we will evaluate the cardiovascular system in a group of children with cystic fibrosis compared with…

A multicenter randomized controlled study of mechanical left ventricular unloading with counterpulsation to reduce infarct size pre PCI for acute myocardial infarction- CRISP-AMI.

To investigate if infarct size can be limited by introduction of IABP prior to intervention.

Acute and chronic administration of the folate derivate levofolinate to patients with acute myocardial infarction: A double-blinded placebo-controlled pilot study.
"Folate in Acute Myocardial Infarction (FolAMI-study)"

A controlled trial to investigate whether by reducing eNOS uncoupling, by direct super oxide scavenging and by up regulating the high-energy phosphate pool, a high dose of intravenous levofolinate can reduce ischemia- and reperfusion-induced…

The effects of nanoparticles and ambient particles on brain function using quantitative electro-encephalography (QEEG) in healthy volunteers

To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…

The effect of two different heart-lung machines, Twin-Pulse Life Support and standard used heart-lung machine, on the systemic inflammation and pattern of microvascular blood flow. A prospective randomised clinical trial.

Analysis of the effects of the Twin-Pulse Life Support on on the systemic inflammatory response and the effect on microvascular blood flow in ocmparison to standard used Extracorporeal Circuit Device

A Self-Regulation Intervention Program for Lifestyle Change in Cardiac Patients

To develop an effective lifestyle intervention for cardiac patients based on self-regulation theory aimed at health behavior change and maintenance.

Study of Myocardial Infarctions in Leiden - Platelets (SMILE-Platelets). Value of platelet function tests in the prediction of cardiovascular events

To examine whether platelet hyperreactivity, as assessed by various platelet activation or function tests, could explain recurrence of cardiovascular events among patients that suffered a first MI.To assess which (combination of) platelet activation…

The effect of rosiglitazone on ischemia-reperfusion-injury using annexin A5 scintigraphy.
A double blind placebo- controlled cross-over study in subjects with the metabolic syndrome

To estimate the effect of rosiglitazone compared to placebo on ischemia-reperfusion injury as assessed by annexin A5 scintigraphy in the human forearm in subjects with the metabolic syndrome.

Multi-locus approach in pharmacogenetics. Application in the cholesterol lowering and anti-inflammatory pathways of statins

The aim of this project is to study SNPs in genes involved in the cholesterol lowering pathway and in the anti-inflammatory pathway of statins to explain differences in the protective effect of statins against myocardial infarction (MI). A second…

Monitoring radiation induced cardiac damage by blood markers

The main objective of this study is to find a correlation between the rise in NT pro BNP level and the radiation dose given to the heart.

Evaluation of the association between heart type fatty-acid binding proteins and high sensitive troponin and postoperative myocardial infarction in patients undergoing cardiac-surgery

The objective is to estimate the association between biomarkers of myocardial injury and myocardial infarction in patients undergoing cardiac surgery. Myocardial infarction will be established with both a new and very early marker of myocardial…

Randomised Controlled Trial for an e-Health application in EUropean Cardiac Rehabilitation programmes in Elderly; Assessment of the effects on sustainablity and participation level of a mobile telemonitoring guided cardiac rehabilitation programma (mCR) and its cost effectiveness, in elderly patients in Europe

The aim of this study is to investigate whether a mobile telemonitoring guided CR (mCR) as alternative for a regular CR programme is an effective means to increase participation and adherence of elderly in a CR programme, and results in better long…

A Phase 2, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-groupStudy to Investigate the Safety and Tolerability of Multiple Dose Administration of CSL112 in Subjects with Moderate Renal Impairment and Acute Myocardial Infarction

The primary objective of this study is to assess the renal safety of CSL112 in subjects with moderate RI and AMI after administration of up to 4 weekly infusions of CSL112.The secondary objectives of the study are:1. To further characterize the…

COVID@Home: cardiovascular disease and risk in non-hospitalized Covid-19 patients

Primary and Secondary: To assess cardiovascular function and the presence and magnitude of myocardial injury using echocardiography and cardiac magnetic resonance (CMR) imaging, among community-dwelling individuals who recovered from Covid-19…

The CRYSTAL study: CMR of intraventricular flow analysis and genetic phenotyping in Hypertrophic Cardiomyopathy (HCM): a roadmap for surgical myectomy

The primary objective of this study is to assess wall shear stress in the left ventricle outflow tract using 4D flow CMR in healthy controls, asymptomatic HCM and before and after surgical myectomy in patients with HOCM,

The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anesthesia (PRETREAT): an adaptive, multicenter randomized controlled trial

The aim of this adaptive multicentre randomized controlled trial is to maintain patients at a target blood pressure level with a sufficient margin from the minimal acceptable blood pressure threshold of a MAP of 65 mmHg to reduce the incidence of…

A PROSPECTIVE MULTINATIONAL STUDY OF THE NATURAL HISTORY OF PARTICIPANTS WITH BAG3 MUTATION ASSOCIATED DILATED CARDIOMYOPATHY

Primary:Determine baseline and changes over time in cardiac structure and function in BAG3 associated DCM.Secondary:Assess the progression of prognostic disease biochemical biomarkers in BAG3 associated DCM.

Seroprevalence Study of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV) in Patients with Plakophilin 2 (PKP2)-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

PrimaryInvestigate the seroprevalence of pre-existing antibodies to AAV in patients with PKP2-associated ARVCSecondaryTo characterize the burden of illness in patients with pathogenic or likely pathogenic PKP2 mutationsTo characterize arrhythmic…