146 results
Primary objectivesTo study whether Geranyl-Geranyl Acetone (GGA) reduces left ventricular (LV) diastolic dysfunction in patients with HFpEF compared to placebo (and to assess/confirm its effectiveness and safety in patients with HFpEF)Secondary…
Primary objective: To determine whether adding information and coaching support to the standard diagnostic testing environment for the inducibility of myocardial ischemia improves patient psychological wellbeing.The role of the testing environment…
The main objective of this event-driven trial is to demonstrate the superiority of empagliflozin 10 mg once daily versus placebo, in addition to standard of care, for the reduction of the composite endpoint of time to first heart failure…
This study has been transitioned to CTIS with ID 2023-508485-15-00 check the CTIS register for the current data. Main study:Primary:Efficacy:- To assess the clinical outcome at 30 days follow-up after administration of a single subcutaneous…
In different stages of HCM, to measure the: - Myocardial perfusion- Myocardial function- Volume parameters of the heart- Fibrosis- Function of the small vessels (endothelial (dys)function)- Diastolic function and strain of the heart
Demonstrate that primary Left Ventricular unloading and a thirty-minute delay-to-reperfusion, when compared to the control cohort, treated according to the current standard of care treatment of Anterior STEMI, has the following effects:1. Reduction…
To determine the feasibility of late enhancement imaging in spectral photon counting CT to detect myocardial infarction and viability
Primary objective To investigate and compare the independent prognostic effects of the different PMI phenotypes (myocardial infarction and noninfarct troponin elevation) and noncardiac MAPE on disability in patients undergoing elective noncardiac…
The main objective is to assess long-term neurodevelopmental, cardiovascular, pulmonary, and growth outcomes in a cohort of MC twins with sFGR and to compare outcomes within sFGR twin pairs.
Primary Objective:- to evaluate whether the oral FXIa inhibitor BAY 2433334 leads to a lower incidence of CV death, MI, stroke and stent thrombosis following an acute myocardial infarction when compared to a placebo- to evaluate whether the…
The objective of the proposed trial is therefore to determine the effect of continuation versus withdrawal of ACEi and ARB in the perioperative period on postoperative complications, expressed as acute kidney injury, myocardial injury, and quality…
The primary objective is to estimate the per patient sensitivity of combined CTCA/dynamic CTP for diagnosis of hemodynamically significant coronary artery disease with ICA/FFR as reference standard.
By performing this study, in case the results are positive (SMS images are equally diagnostic as compared to current imaging techniques), the SMS sequence can be implemented in standard clinical care for patients referred for cardiac MRI, reducing…
The aim of this adaptive multicentre randomized controlled trial is to maintain patients at a target blood pressure level with a sufficient margin from the minimal acceptable blood pressure threshold of a MAP of 65 mmHg to reduce the incidence of…
Primary objective Primary objective is to create a prediction model based on early clinical screening of motor, cognitive, and emotional disturbances to predict restrictions in participation at one year after cardiac arrest in patients that have…
This study has been transitioned to CTIS with ID 2024-513310-36-01 check the CTIS register for the current data. Primairy objectives 1. To determine the presence and extent of myocardial microcalcification and myocardial denervation in ATTR-CM;2. To…
The aim of this registry is to compare functional status among patients with highly symptomatic obstructive HCM despite optimal medical treatment who undergo Alcohol Septal Ablation to Surgical Septal Myectomy. This study will therefore, compare the…
In patients with symptomatic New York Heart Association (NYHA) Class II/III/IV dilated cardiomyopathy (DCM) in which mutations in the gene encoding the lamin A/C protein (LMNA) have been implicated:Primary Objective:* NYHA Class II/III patients only…
The objective of the the BIO|GUARD-MI study is to investigate whether the early diagnosis of cardiac arrhythmias, provided by the BioMonitor in connection with remote monitoring, and the consequent treatment of the patient will decrease the risk to…
To determine whether a standardized exercise workload elicits a different response on 1) metabolites/cardiac biomarkers in the general circulation (measured by blood values), and 2) contraction patterns in local myocardium (measured by…