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An open-label, multicenter, extension study to evaluate the long-term safety and tolerability of LOU064 in eligible subjects with CSU who have participated in preceding studies with LOU064

To assess the long-term safety and tolerability of LOU064 in patients with CSU who have participated in preceding studies with LOU064.

Investigation of flare and remission in atopic dermatitis in an integrated longitudinal study: effects of systemic treatment with cyclosporine A

What has so far been underexplored in the study of molecular signatures in atopic dermatitis is a wide systems biology approach, in which multiple analysis techniques (a so-called multi-omics approach) are applied in a clinical setting where…

Randomized, double blind, multicenter extension to CZPL389A2203 dose-ranging study to assess the shortterm and long-term safety and efficacy of oral ZPL389 with concomitant or intermittent use of TCS and/or TCI in adult patients with atopic dermatitis (ZEST Extension)

The purpose of this study is to assess short-term and the long-term safety and efficacy of oral ZPL389 (30 mg once daily (o.d.) and 50 mg o.d.) when used concomitantly or intermittently with topical corticosteroid (TCS) and/or topical calcineurin…

A Phase 3b Multicenter, Randomized, Double-Blind, Double-Dummy, Active Controlled
Study Comparing the Safety and Efficacy of Upadacitinib to Dupilumab in Adult Subjects with Moderate to Severe Atopic Dermatitis.

The objective of this study is to evaluate the efficacy and safety of upadacitinib versus dupilumab for the treatment of adult subjects with moderate to severe atopic dermatitis who are candidates for systemic therapy.

A Randomized, Double Blind, Placebo Controlled, Phase 2a Study to Assess the Clinical Efficacy of ISIS 721744, a Second Generation Ligand Conjugated Antisense Inhibitor of Prekallikrein, in Patients with Hereditary Angioedema

The primary objective of the study is to evaluate the clinical efficacy of antisense inhibitor of prekallikrein (ISIS 721744) in patients with hereditary angioedema (HAE) type 1 (HAE 1), HAE type 2 (HAE 2), or HAE with normal C1-inhibitor (C1-INH).…

Injection of Autologous Stromal Vascular Fraction enriched lipoaspirate for the treatment of vulvar Lichen Sclerosus - a pilot study

To quantify clinical and histological improvements in patients with vulvar lichen sclerosus after treatment with SVF enriched lipofilling.

Handheld Laser Speckle Contrast Imaging Device for optical microcirculatory perfusion imaging: Clinical, therapeutic and pathophysiological implications for adult- and paediatric psoriasis.

Our objectives in both adult and paediatric psoriasis patients are (I) To validate the Handheld LSCI Device for visualization of vascular changes within psoriatic plaques. (II) Identification of the most active and least active sides of psoriatic…

A multicenter, randomized, double-blind, placebocontrolled Phase 2b dose-finding study to investigate the efficacy, safety and tolerability of LOU064 in adult chronic spontaneous urticaria patients inadequately controlled by H1-antihistamines

The primary objective of this study is to characterize the dose-response relationship of LOU064 administered once or twice daily in subjects with CSU with respect to change from baseline in UAS7 at Week 4.

Early clinical and biomarker responses after treatment in patients with non-segmental vitiligo

- Assess whether early markers (in blood and/or skin) can predict the clinical response to treatment (i.e. surface area of repigmented skin after 3 and 6 months of standard of care treatment).- Assess the relation between markers in blood, skin…

A Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety and Efficacy of Risankizumab in Adult Subjects with Moderate to Severe Hidradenitis Supperativa.

The objective of this study is to assess the safety and efficacy of 2 dose levels of risankizumab versus placebo for the treatment of signs and symptoms of moderate to severe Hidradentitis Supperativa in adult subjects diagnosed for at least one…

The effect of psychological intervention on the quality of life and wound healing in patients with diabetic foot ulcer

The aim of this study is to evaluate the effect of psychological intervention on the quality of life and wound healing in patients with a foot ulcer.

Assessment of the protective effect of sunscreen by measuring UV-biomarkers

Determine the protective effects of sunscreens against UV-radiation by measuring biomarkers in the stratum corneum.

EVALUATION OF BIOMARKERS OF ATOPIC DERMATITIS IN PEDIATRIC
PATIENTS WHOSE DISEASE IS NOT ADEQUATELY CONTROLLED WITH TOPICAL
PRESCRIPTION THERAPIES OR WHEN THOSE THERAPIES ARE NOT MEDICALLY
ADVISABLE

To explore associations between biomarkers of atopic dermatitis(AD) and:• Disease state and time course of AD,• Disease state and evolution of selected atopiccomorbid conditions,• Effectiveness of specific AD treatments.

Discovery of Arthritis in Psoriasis Patients for Early Rheumatological referral (DAPPER

To ascertain the prevalence of PsA in a tertiary PsO cohort. Secondary objectives will be to ascertain the clinical features of these patients. With these features we want to find clinical, laboratory or genetic markers to predict the presence of…

A randomized, placebo-controlled, double-blind phase I study to explore safety, tolerability and pharmacodynamics of Cypep-1 in subjects with cutaneous warts

* To evaluate the safety and tolerability of CyPep-1 when applied on healthy skin for up to one week. * To evaluate the safety and tolerability of CyPep-1 when applied to cutaneous warts for up to four weeks.* To evaluate the activity of the CyPep-1…

An open-label, randomised, Phase IV study, to assess the efficacy and safety of tildrakizumab in patients with moderate-to-severe chronic plaque psoriasis who are non-responders to dimethyl fumarate therapy.

Primary objectiveTo assess the efficacy of tildrakizumab treatment (as assessed by PASI 75) in moderate-to-severe plaque psoriasis patients who are non-responders to DMF. Secondary objectivesTildrakizumab- To assess the efficacy of tildrakizumab…

Long-term physical activity and fitness after pediatric burns

Investigate the long-term recovery of physical activity and physical fitness following pediatric burns, and link the results of former participants to their scores obtained during the initial six months.

A phase 1, open-label, non-randomized, 2-period, fixed sequence study to investigate the absorption, distribution, metabolism and excretion of 14C-PF-06651600 and to assess the absolute bioavailability and fraction absorbed of PF-06651600 in healthy male participants using a 14C-microtracer approach

The purpose of this study is to investigate how quickly and to what extent PF-06651600 is absorbed and eliminated from the body (this is called pharmacokinetics). In this study doses of PF-06651600 labeled with very low doses radioactive (14C) will…

A Randomized, Double-Blind, Vehicle-Controlled, Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Topically Applied INM-755 Cream in Healthy Volunteers

Part 1Primary ObjectiveTo evaluate the local and systemic safety and tolerability of INM-755 cream following repeated once-daily topical applications for 14 days on healthy skin of healthy volunteersSecondary ObjectiveTo assess the local and…

An open-label, multi-centre drug-drug interaction trial to investigate the effects of tralokinumab on the pharmacokinetics of selected cytochrome P450 (CYP) substrates in adult subjects with moderate-to-severe atopic dermatitis

Primary objectiveTo evaluate if tralokinumab after 14 weeks of treatment (at steady state) changes the metabolism of substrates of CYP 1A2, 2C9, 2C19, 2D6, or 3A4 pathways in subjects with moderate-tosevere atopic dermatitisSecondary objectivesTo…