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Capillaroscopy in patients with early Raynaud

zie Nederlandse samenvatting

Critical Limb Ischemia: Perfusion Computed Tomography.

The main objective of this study is to assess perfusion of the foot and correlate perfusion values with arterial patency. To this end, first the PCT protocol of the foot in patients with CLI needs to be optimized in terms of contrast dose…

Non-invasive imaging of perfusion and oxygenation of the LOWer extremities in healthy volunteers by means of Multispectral Optoacoustic Tomography (LOW-MSOT)

To investigate the possibility to measure non-invasively perfusion and oxygenation in static physiological conditions in the lower leg using MSOT.

The development and validation of models of human skin diseases for drug testing

To develop and validate transplant models of vitiligo and atopic dermatitis for drug testing.

Capillary malformations, from genotype to phenotype: a focus on endothelial function

We aim to provide preliminary information on the presence of GNAQ, GNA11, RASA1 or PIK3CA gene mutations, assess the endothelial cell properties and compare it to the phenotypic characteristics of the PWSs of affected patients. This will lead to a…

Assessment of microcirculation in the diabetic foot with photoacoustic imaging

Investigate the stability and reproducibility of PAI when applied to the diabetic foot. Further, we aim to compare results from PAI with the currently used non-invasive blood pressure measurements.

Comparison of Laser Speckle Contrast Imaging (LSCI) and Laser Doppler Imaging (LDI)

o To test the linearity of the LSCI device (Perimed AB, Järfälla, Sweden) and LDI device (Moor Instruments, Devon, UK) in a wide range of blood flux valueso To compare arbitrary units of two different kinds of laser-based devices and to create a…